Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats

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dc.contributor.authorFaysal Selimoğlu
dc.contributor.authorMustafa Cengiz
dc.contributor.authorCanan Vejselova Sezer
dc.contributor.authorAdnan Ayhanci
dc.contributor.authorFatma Gür
dc.contributor.authorÖzge Yıldırım
dc.contributor.authorBahri Gür
dc.contributor.authorAhmet Musmul
dc.date.accessioned2025-04-16T08:17:15Z
dc.date.available2025-04-16T08:17:15Z
dc.date.issued2025-04-07
dc.departmentFakülteler, Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümü
dc.description.abstractThe purpose of this study is to measure the effects of acrylamide (AA) on bone marrow and blood and the protective efficacy of boric acid (B) in rats. The animals were divided into five groups: control, B, low-dose B + AA, and high-dose B + AA. After the 15 th day of the experiment, their blood and bone marrow were harvested to be kept for hematological analyses. While white blood cells (WBC) increased following the administration of AA, bodyweight, red blood cells, platelets, hemoglobin, hematocrit, and bone marrow nucleated cell counts significantly decreased in number. Conversely, bodyweight and all these hematological parameters significantly increased apart from WBC in the B + AA groups AA when compared to the control. However, high-dose B was more effective than low-dose B in preventing AA-induced bone marrow and hematological damage. The present study suggests that B treatment could help protect bone marrow and hematological parameters against AA-induced toxicity.
dc.identifier.citationSelimoğlu, F., Cengiz, M., Vejselova Sezer, C., Ayhanci, A., Gür, F., Yıldırım, Ö., ... & Musmul, A. (2025). Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats. Biological Trace Element Research, 1-8.
dc.identifier.doi10.1007/s12011-025-04610-4
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.pmid40193000
dc.identifier.scopus2-s2.0-105002177466
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s12011-025-04610-4
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8614
dc.identifier.wos001461139300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorCengiz, Mustafa
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcrylamide
dc.subjectBoron
dc.subjectHematologic toxicity
dc.subjectMyelotoxicity
dc.subjectRats
dc.titleBoron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats
dc.typejournal-article

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