Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats
Yükleniyor...
Tarih
2025-04-07
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Science and Business Media LLC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The purpose of this study is to measure the effects of acrylamide (AA) on bone marrow and blood and the protective efficacy of boric acid (B) in rats. The animals were divided into five groups: control, B, low-dose B + AA, and high-dose B + AA. After the 15 th day of the experiment, their blood and bone marrow were harvested to be kept for hematological analyses. While white blood cells (WBC) increased following the administration of AA, bodyweight, red blood cells, platelets, hemoglobin, hematocrit, and bone marrow nucleated cell counts significantly decreased in number. Conversely, bodyweight and all these hematological parameters significantly increased apart from WBC in the B + AA groups AA when compared to the control. However, high-dose B was more effective than low-dose B in preventing AA-induced bone marrow and hematological damage. The present study suggests that B treatment could help protect bone marrow and hematological parameters against AA-induced toxicity.
Açıklama
Anahtar Kelimeler
Acrylamide, Boron, Hematologic toxicity, Myelotoxicity, Rats
Kaynak
Biological Trace Element Research
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
Sayı
Künye
Selimoğlu, F., Cengiz, M., Vejselova Sezer, C., Ayhanci, A., Gür, F., Yıldırım, Ö., ... & Musmul, A. (2025). Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats. Biological Trace Element Research, 1-8.
