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Öğe Discharge performance of side gates with different shapes(IWA Publishing, 2025-02-10) Veysi Kartal; M. Emin Emiroglu; M. Fatih YukselFlow measurement and water level control in open channels are vital to water management. Lateral intake structures are commonly used for different purposes in civil and environmental engineering applications. Flow characteristics of rectangular, triangular, and semi-circular shapes were experimentally investigated using 357 runs under subcritical flow conditions. Correlation analysis was conducted to determine the effect of various parameters on the discharge coefficient. Upstream Froude number (F1), the ratio of the gate opening to the upstream flow depth, and the gate length to flow depth ratio are influential for all side gates. However, the ratio of the gate opening to the gate length is also influential for triangular side gates. Discharge coefficient of the semi-circular side gate is relatively higher than that of the other tested gates within the range of 0.05Öğe Uncertainty and Well-Being in Turkish Adults: Exploring the Role of Religiosity and Psychological Symptoms(Springer Science and Business Media LLC, 2025-02-27) Nuri Türk; Gökmen Arslan; Alican Kaya; Oğuzhan YildirimReligiosity offers individuals a sense of purpose and connection, which can lead to greater life satisfaction and improved psychological well-being and happiness. On the other hand, psychological challenges such as depression, anxiety, stress, and difficulty dealing with uncertainty can negatively affect life satisfaction. This study examined these dynamics using a hypothetical model, incorporating mediation and moderation analyses to explore the connections between intolerance of uncertainty, life satisfaction, religiosity, and psychological symptoms in a group of 565 participants (286 of whom were female). The findings revealed notable positive and negative relationships among these variables. Specifically, the study found that (i) religiosity and psychological symptoms both play a mediating role in the link between intolerance of uncertainty and life satisfaction, and (ii) religiosity serves as a moderator in this relationship. The moderation analysis showed that when religiosity levels are low, the negative effect of intolerance of uncertainty on life satisfaction is significantly stronger. In contrast, high levels of religiosity significantly weaken this negative relationship, indicating that religiosity acts as a buffer against the adverse impact of uncertainty on life satisfaction. These results underscore the potential value of religiosity in helping individuals cope with the harmful effects of uncertainty on their sense of life satisfaction. Additionally, lower levels of psychological symptoms and reduced intolerance of uncertainty were associated with higher life satisfaction, suggesting that religiosity may play a protective role in promoting overall well-being.Öğe Wild Emmer (Triticum turgidum ssp. dicoccoides) Diversity in Southern Turkey: Evaluation of SSR and Morphological Variations(MDPI AG, 2025-01-29) Esra Çakır; Ahmad Alsaleh; Harun Bektas; Hakan ÖzkanWild emmer wheat (Triticum turgidum ssp. dicoccoides) is the ancestral species of cultivated tetraploid wheat with BBAA genomes. Because of its full interfertility with domesticated emmer wheat, this wild species can serve as one of the most important genetic resources to improve durum and bread wheat. To clarify the magnitude of genetic diversity between and within populations of Turkish wild emmer wheat, 169 genotypes of ssp. dicoccoides selected from the 38 populations collected from the three sub-regions (East-1, West-1, and West-2) of the Southeast Anatolia Region of Turkey were molecularly and morphologically characterized. The populations showed significant variation in plant height, heading date, flag leaf area, spike length and number, spikelet, peduncle, lemma, palea, glume and anther lengths, glume hull thickness, anther width, and days to maturity. According to the results of nuclear-SSR analysis, the populations collected from the sub-regions East-1 and West-2 were the most genetically distant (0.539), while the populations collected from the sub-regions West-1 and West-2 were the most genetically similar (0.788) populations. According to the results of AMOVA, there was 84% similarity within the populations studied, while the variation between the populations of the three sub-regions was 16%. In the dendrogram obtained by using nuclear-SSR data, the populations formed two main groups. The populations from the sub-region East-1 were in the first group, and the populations from the sub-regions West-1 and West-2 were in the second group. From the dendrogram, it appears that the populations from the sub-region East-1 were genetically distant from the populations from the sub-regions West-1 and West-2. The results highlight the potential diversity in Southeast Anatolia for wild emmer discovery and utilization.Öğe 3D Geometric Morphometric Analysis of Calcaneal Morphology in Domestic Caprinae: Sheep (Ovis aries) and Goat (Capra hircus)(MDPI AG, 2025-02-14) Barış Can Güzel; Tomasz Szara; Burak Ünal; Sokol Duro; Fatma İşbilir; Funda Yiğit; Mihaela-Claudia Spataru; Karolina Goździewska-Harłajczuk; Ozan GündemirThe calcaneus plays a critical role in balance, locomotion, and muscle attachment, making it a key structure for biomechanical adaptations. This study examined interspecies differences between sheep and goats, as well as intraspecies variations among different sheep breeds, in calcaneus morphology. A total of 128 right calcanei were analyzed using 3D geometric morphometric methods to allow detailed assessments of calcaneus shape and size. Among sheep, the Hamdani sheep displayed the largest calcaneus among the breeds, distinguishing them significantly from the others. In contrast, goats had a bilaterally narrower calcaneal body, while sheep featured a more pronounced distal portion that articulates with the talus and a deeper articular surface. Additionally, the sustentaculum tali were more developed in sheep. The bilaterally compressed calcaneal body in goats likely reflects their agility and ability to navigate steep, rocky terrains. In contrast, sheep's broader and more robust calcaneus may support their grazing lifestyle on flatter terrains, emphasizing their stability and weight-bearing capacity. These findings highlight the functional significance of calcaneal morphology in the locomotor strategies and physical capabilities of goats and sheep, providing valuable insights for comparative anatomy and veterinary science.Öğe Abundant soliton solutions in saturated ferromagnetic materials modeled via the fractional Kraenkel–Manna–Merle system(Springer Science and Business Media LLC, 2025-02-25) Loubna Ouahid; Maryam Alshahrani; A. Mohamed Abdel-Baset; M. A. Abdou; Ali Akgül; Murad Khan HassaniThe Modified Generalized Riccati Equation Mapping Technique is employed to discover novel solutions for the Fractional Kraenkel-Manna-Merle system. In this system, a nonlinear of ultra_short wave pulse propagates across saturated ferromagnetic-materials by very low conductance. The beta-derivative is used to analyze the fractional performance of the proposed system. Combo-multi soliton shape, anti-bell-shaped solitons, kink bright-dark shape are the results of the applications. The results obtained are original and unfamiliar to the reader, as they had not been published previously. For a few chosen solutions, two dimensional, and three dimensional are shown to offer important insights into the behavior and properties of the solutions. These detailed exact solutions and wave phenomena contribute to a deeper understanding of this equation. This work opens up new possibilities for exploring wave phenomena in more complexly structured nonlinear.Öğe Skull morphology in native and non-native cattle breeds in Türkiye.(2025-02-23) Gündemir, Ozan; Manuta, Nicoleta; Güzel, Barış Can; Bakıcı, Caner; Duro, Sokol; Ünal, Burak; Çakar, Buket; Szara, TomaszThis study aims to investigate morphological differences in the skulls of cattle breeds with different functional roles and geographical origins and to examine skull shape variations among breeds using geometric morphometrics methods. To this end, 95 skulls from Native (Eastern Anatolian Red and Southern Anatolian Red) and Non-native (Holstein and Simmental) breeds raised in Türkiye were analyzed. The results show a significant size difference between Native Breeds and Non-native Breeds, with the Non-native Breeds having larger skulls. The results also indicate considerable shape differences between Native and Non-native Breeds. No significant shape differences were observed between the two Native Breeds, which have shared the same geography for many years. Although no statistically substantial size difference was found between Simmental and Holstein, the nuchal region showed distinct shape differences. The nuchal part of the Simmental skull was more pronounced than other specimens. In native breeds, there was a more balanced proportion between the facial and neurocranial regions compared to the other two breeds. In Holstein skulls, the facial region was more pronounced in comparison to the neurocranial region, while in Simmental skulls, the neurocranial region was more prominent. This study provides valuable insights into the morphological characteristics of different cattle breeds, contributing to veterinary anatomy, biology, and paleontology.Öğe A new plentiful solutions for nanosolitons of ionic (NSIW) waves spread the length of microtubules in (MLC) living cells(Springer Science and Business Media LLC, 2025-02-20) Loubna Ouahid; M. A. Abdou; Jameelah S. Al Shahrani; A. Mohamed Abdel-Baset; Ali Akgül; Murad Khan HassaniThis article describes the developed Paul-Painlike method (PPM) to provide striking ODE of the nanosoliton of the ionic waves (NSIW) that spread the length of microtubules in live cells. Furthermore, Auxiliary Equation Approach (AEA) and Sardar Sub Equation Approach (SSEA) have been utilized similarly and concurrently to determine solutions for this particular model. In providing a physical explanation, various solitary wave structures are visually represented. These solutions include the anti-kink, kink shape, singular kink wave shape, and periodic bright, bright-dark and dark-singular soliton solution. Additionally, graphical illustrations (both 2-D and 3-D) demonstrate how the various parameters utilized affect the validity of analytical results. Furthermore, the uniqueness of the solutions we derived is highlighted by comparing the differences with earlier solutions of the model. The solutions produced may be beneficial in a number of significant investigations in medicine, as well as biology. The results demonstrate the effectiveness of the proposed techniques for determining many optical solitons of nonlinear evolution equations.Öğe Investigation of the effects of propofol and sevoflurane anesthesia on oxidant-antioxidant status and biochemical parameters in Turkish hair goats(American Veterinary Medical Association (AVMA), 2025-02-17) Ali Gülaydın; Kıvanç İrak; Nihat Şındak; Mustafa Barış Akgül; Özgür Yaşar Çelik; Onur Yıldırım; Maruf Yılmaz; Erman GülendağObjective: To investigate the effects of propofol and sevoflurane anesthesia on the oxidant-antioxidant status and biochemical parameters in Turkish hair goats. Methods: The study was conducted from February 15 through March 15, 2024. Seven clinically healthy female Turkish hair goats aged 1 to 2 years with an average live weight of 29.95 (26.1 to 33.8) kg were included. A bolus of propofol (6 mg/kg) was injected IV. The goats were placed in the sternoabdominal position and administered 1% to 3% sevoflurane with 100% oxygen for 2 hours with the help of a vaporizer. Blood samples were collected before and after the administration of propofol and at the 15th, 30th, 60th, and 120th minutes after the start of sevoflurane administration in nonanticoagulated tubes. The oxidant-antioxidant status (serum total antioxidant status, total oxidant status, paraoxonase activity, and arylesterase activity) and biochemical parameters (levels of glucose, AST, GGT, ALT, ALP, LDH, creatine kinase, amylase, lipase, creatinine, urea, uric acid, high-density lipoprotein, low-density lipoprotein, total protein, albumin, total bilirubin, direct bilirubin, magnesium, chlorine, calcium, iron, sodium, phosphorus, and potassium) were evaluated. The heart rate, respiratory rate, and body temperature of the goats were measured using a bedside monitor. Results: Arylesterase activity increased with sevoflurane administration. Changes were observed in heart rate and body temperature as well as in the levels of glucose, creatine kinase, urea, total bilirubin, and potassium at different time intervals of propofol-sevoflurane administration. Conclusions: Propofol-sevoflurane anesthesia has no adverse effects on oxidant-antioxidant status in Turkish hair goats. Clinical relevance: The evaluation of heart rate and body temperature, as well as glucose, creatine kinase, urea, total bilirubin, and potassium levels, must be considered in propofol-sevoflurane anesthesia protocol.Öğe Effects of propolis supplementation during cryopreservation of ram semen.(2024) Güngör, I H; Özer Kaya, Ş; Dayan Cinkara, S; Çakır Cihangiroğlu, A; Kaya, E; Acısu, T C; Erdem Erişir, F; Yılmaz, Ö; Yılmaz, S; Gür, S; Sönmez, M; Türk, GBackground: Cryopreservation of ram semen is a very challenging process. Loss of motility during freezing does not allow artificial insemination of rams. Aims: This study aimed to determine whether the inclusion of liquid propolis extract in semen diluents affects the cryopreservation efficiency of ram semen. Methods: Six Akkaraman breed rams were considered for semen study. Semens were combined with Tris+egg yolk extender containing and without (control) propolis at different concentrations (0.25%, 0.50%, 1%, 2%, and 4%). Semen was frozen using routine ram semen freezing procedures. After thawing, motility and kinematic parameters were analyzed by computer assisted semen analysis (CASA), and viability, acrosomal damage level and mitochondrial membrane potential were analyzed by flow-cytometer in all groups. Additionally, fatty acid levels in total semen were analyzed using gas chromatography (GC), and vitamin and cholesterol levels were analyzed using high-performance liquid chromatography (HPLC). In addition, oxidative stress, HOS test, and morphological analyzes were performed after freezing and thawing. Results: The 0.5% propolis group showed a significant increase in total and rapid motility, LIN, membrane integrity, and antioxidant levels compared to the control, and a significant decrease in malondialdehyde (MDA) and low mitochondrial membrane potential (LMMP) levels. Compared to the control, the group containing 4% propolis damaged spermatozoa and caused a significant decrease in total, progressive and rapid motility and high mitochondrial membrane potential (HMMP), Glutathione S-transferase (GST), and catalase (CAT) levels. Conclusion: We showed that adding 0.5% propolis to semen extenders to increase the freezability level of ram semen increases the survival of spermatozoa after freeze-thaw and ensures the success of freezing.Öğe Shape and Size Variations in the Astragalus of Large and Small Bovids(MDPI AG, 2025-02-03) Burak Ünal; Barış Can Güzel; Buket Çakar; Yeşim Aslan Kanmaz; Funda Yiğit; Ozan Gündemir; Mihaela-Claudia SpataruThe astragalus acts as a crucial intermediary in the tarsal joint, facilitating the transfer of body weight to the lower extremities while also ensuring both stability and mobility through its articulation with adjacent bones, enabling efficient movement. This study investigates the morphological diversity of the astragalus in three modern cattle breeds, one goat breed, and three sheep breeds using three-dimensional geometric morphometric methods. A total of 225 specimens were analyzed in this study. Large bovids, such as the Holstein and Simmental cattle breeds, had a more developed lateral edge of the proximal trochlea and a more rounded astragalus. In small bovids, the Akkaraman and Morkaraman sheep breeds displayed a more prominent medial edge and a rounded astragalus form, while the Hair goat breed exhibited a rectangular structure with a well-developed lateral projection. The results of this study demonstrate that the astragalus serves as a reliable morphological marker for differentiating between large and small bovids, as well as between closely related taxa such as sheep and goats. These shape variations, particularly observed in the proximal trochlea, reflect functional adaptations to size, body mass, and locomotor demands, making the astragalus a critical element for taxonomic identification and biomechanical analysis.Öğe Development of Trivariate Multiscalar–Standardized Drought Index (TMSDI) for assessing drought characteristics(Springer Science and Business Media LLC, 2025-02-11) Aamina Batool; Veysi KARTAL; Zulfiqar AliDrought is an extensive natural hazard influenced by human activities. Drought has a substantial impact on environmental systems and socioeconomic activities globally, posing serious challenges to water resources, agriculture, and ecosystems. Drought as a complicated natural occurrence is difficult to monitor and anticipate. However, to address the detrimental issues of drought, this study examined the innovative Trivariate Multiscalar-Standardized Drought Index (TMSDI). The climatic factors of precipitation, temperature, and Normalized Difference Vegetation Index (NDVI) are components in the development of TMSDI. To check the association of the innovative index with the another drought indices, this study evaluated correlations between the proposed index (TMSDI) and traditional drought indices, i.e., the Standardized Precipitation Index (SPI) and the Standardized Precipitation Temperature Index (SPTI) at 1-, 3-, 6-, 9-, 12-, 24-, and 48-month time scales. The outcomes demonstrate that there is a consistent relationship between the TMSDI and SPI due to higher values of correlation. The lower correlation between TMSDI and SPTI shows that there is a substantial and consistent relationship between TMSDI and SPI than TMSDI and SPTI. Moreover, the long-term behavior of different drought conditions indicates that extreme drought is more likely than extreme wet across the Markov chain's Steady States Probabilities (SSPs). Consequently, the proposed index (TMSDI) is recommended as an effective tool to precisely and accurately monitor drought conditions over different time scales within different climate factors.Öğe Dose-Dependent Application of Silver Nanoparticles Modulates Growth, Physiochemicals, and Antioxidants in Chickpeas (Cicer arietinum) Exposed to Cadmium Stress(American Chemical Society (ACS), 2025-02-05) Abeer Elhakem; Jiahao Tian; Hilal Yilmaz; Wenjing Mao; Lisong Shao; Sipan Soysal; Mohammad Faizan; Jian Gao; Pravej AlamThe present study was intended to investigate the effects of silver nanoparticles (Ag NPs) on chickpea plants grown in cadmium (Cd)-contaminated soil. Chickpea seeds sown in earthen pots (filled with soil) were subjected to Cd stress (100 μM) in the form of CdCl2 (10 mL) 10 days after sowing (DAS). Exogenous applications with Ag NP concentrations 50, 100, and 200 μM were used to observe their effects on Cd-stressed plants. Growth, biochemical, and stress parameters were studied. Results showed that Ag NPs positively affected plant growth and ameliorated the toxic effects of Cd stress. Plant height, fresh weight, dry weight, total carotenoid content, rubisco activity, and net photosynthetic rate (PN) were significantly decreased by Cd stress but enhanced by 28, 29, 31, 30, 33, and 35%, respectively, by foliar application of Ag NPs. Similarly, Ag NPs increased the activity of superoxide dismutase (61%), catalase (58%), and peroxidase (68%) and reduced the malondialdehyde (28%) and hydrogen peroxide (23%) in chickpea plants. Protein content was also increased by the application of Ag NPs (16%). Furthermore, the addition of Ag NPs decreased the plant Cd content. According to the current study, adding Ag NPs to plants under Cd stress improved their growth and photosynthesis by reducing Cd absorption and improving plant stress tolerance. © 2025 The Authors. Published by American Chemical Society.Öğe Music Therapy may Decrease Radial Artery Spasm Rates and Increase Satisfaction during Coronary Angiography(Bentham Science Publishers Ltd., 2025-02-04) Muzaffer Aslan; Doğaç Okşen; Yunus Emre Yavuz; Çağdaş KaynakIntroduction: With the widespread use of the radial artery in catheterization procedures, radial artery spasm (RAS) is frequently considered an undesirable event. It is known that anxiety increases RAS, and listening to music helps individuals control anxiety during the procedure. This study aimed to investigate the effects of music concerts on RAS. Methods: In this prospective study, imaging and interventional coronary catheterization procedures using the radial artery were included. One group listened to a musical recital during the procedure, while the other group was treated in a quiet environment. The demographics, procedural parameters, and complications of both groups were compared. Results: The study included a total of 147 patients, with an average age of 51.6 ± 11.1 years. Of these, 78 patients (53%) listened to music, while 69 patients (46.9%) underwent catheterization in a quiet environment. The impact of music therapy on the RAS was found to be significant (11.5% vs. 20.3%; p=0.035). While music therapy showed a potential to reduce RAS rates, its effect was not statistically significant in multivariate analysis (p=0.055). Conclusion: Music is a feasible, simple, and inexpensive method for reducing anxiety levels in patients. Listening to music during catheterization can reduce procedural discomfort and the frequency of undesirable events by helping people control their anxiety.Öğe New exact soliton wave solutions appear in optical fibers with Sardar sub equation and new auxiliary equation techniques(Springer Science and Business Media LLC, 2025-02-05) Umair Asghar; Muhammad Imran Asjad; Yasser Salah Hamed; Ali Akgul; Murad Khan HassaniThis paper comprehensively analyzes exact solutions for the nonlinear long-short wave interaction system within the optical field. Consider two general techniques in this field, the Sardar sub-equation method, and a new auxiliary-equation technique. These methods are applied to derive a wide range of soliton solutions for nonlinear partial differential equations. By transforming the original partial differential equation into an ordinary differential equation using an appropriate transformation, various types of solitary wave solutions are obtained. The novelty of this work lies in the application of two powerful analytical methods. The study significantly broadens the scope of these techniques and their applications, providing a diverse set of exact solutions. To enhance comprehension, the obtained solutions are visualized through 3D, 2D, contour, and density plots, offering clear insights into the dynamics of solitary waves. Long-short-wave interaction model has many applications in different kinds of areas such as in optical fiber communication, to understand the interaction between different wave components that can influence the transmission of signals. This model is used to study the interaction between ion-acoustic waves and electron plasma waves. This helps in understanding energy transfer and wave stability in plasma, which is essential for applications like fusion energy research and space plasma. This is important in coastal engineering for predicting wave behaviors that affect coastal structures, sediment transport, and tsunami dynamics.Öğe Optical hausdorff quantum energy of spherical magnetic particles(Springer Science and Business Media LLC, 2025-02-04) Talat Körpinar; Zeliha Körpinar; Hatice özdemir; ALi Akgül; Murad Khan HassaniIn this article, a new approach for spherical magnetic curves under the spherical system in spherical space is given. Firstly, the Hausdorff derivative of the Lorentz spherical magnetic fields [Formula: see text] [Formula: see text] [Formula: see text] of spherical magnetic curves is constructed. On the other hand, the Lorentz spherical magnetic fields, by considering the Hausdorff derivative definition, are presented. Eventually, the Hausdorff energies of these spherical Lorentz fields according to the spherical system in [Formula: see text] spherical space are computed.Öğe Mitigating drought stress in fenugreek through synergistic effects of alanine and potassium-enriched biochar(Springer Science and Business Media LLC, 2025-02-03) Wanzheng Ma; Xinyu Fang; Mengru Qiu; Misbah Hareem; Zeki Erden; Çağdaş Can Toprak; Abdullah A. AlarfajDrought stress adversely affects plant growth, development, and yield. It can decrease seed germination, biomass accumulation, root proliferation, chlorophyll contents, and stomatal conductance. To overcome this critical issue, researchers suggest employing environmentally friendly approaches. The exogenous application of alanine (AL) acts as an osmolyte, which helps balance the cellular water under drought stress. It can also improve root architecture, biomass accumulation, and plant fertilizer use efficiency. Applying biochar can improve soil structure, water, and nutrient retention in soil, which are allied factors in enhancing plant growth under drought stress. Furthermore, the enrichment of potassium (K) in biochar also increases its availability to plants, directly regulating the stomatal conductance to alleviate drought stress. That's why the current study aims to explore the combined effect of AL and potassium-enriched biochar (KBC) on fenugreek cultivated under drought stress. Four levels of AL (control, 2mM, 4mM, and 6mM) were applied with 0%, 1%, and 2% KBC in three replicates. Results showed that 2mM AL + 2%KBC showed significant improvement in plant length (5.24%), plant fresh weight (25.36%), plant dry weight (16.23%), chlorophyll a (7.80%), chlorophyll b (15.83%), total chlorophyll (10.65%) over the control under drought stress. A significant increase in shoot N, P, and K concentration compared to control under drought stress also validated the effectiveness of 2mM AL + 2%KBC. In conclusion, 2mM AL + 2%KBC is an effective amendment for alleviating drought stress in fenugreeks. Under drought stress, growers are recommended to apply 2mM AL + 2%KBC to achieve better fenugreek growth.Öğe Distribution of Heat Shock Proteins 27, 60, 70, 90 in Testis and Epididymis of the Domestic Cats (Felis catus) and Dogs (Canis lupus familiaris).(Wiley, 2025-02) Banu Kandil; Alev Gürol BayraktarogluThis study aimed to examine the immunoexpression of HSP27, HSP60, HSP70, and HSP90 in the testis and epididymis of domestic cats (Felis catus) and dogs (Canis lupus familiaris). Testis and epididymis tissues from 6 adult cats and 6 adult dogs were used in this study. Immunohistochemical staining was done to determine the expression of HSPs. In cats and dogs, while HSP60 was detected only in Leydig cells, HSP90 was determined only in spermatogonia. HSP27 was observed only in smooth muscle cells of blood vessels. HSP70 was not detected in spermatocytes, spermatids, Leydig cells, or Sertoli cells, whereas HSP70 was determined in peritubular myoid cells. In addition, unlike cats, HSP70 was observed in spermatogonia of dog testes. HSP27 was determined in basal cells of the epididymal epithelium and smooth muscle cells of the ductal wall in all sections of the epididymis. However, no HSP60 was observed in the epididymis. While HSP70 was not detected in the epididymis of the cats, HSP70 was observed in basal cells of all sections of the epididymis of the dogs. While the epididymal epithelial cells showed HSP90 immunoreactivity in all parts of the epididymis, the smooth muscle cells of the ductal wall exhibited HSP90 immunoreactivity only in the cauda epididymidis. The findings of this study indicate that HSP27, HSP60, HSP70, and HSP90 exhibit different immunoexpression patterns in the testis and epididymis of cats and dogs and that these proteins play important roles in maintaining the reproductive functions of cats and dogs.Öğe Evaluation of the Accuracy and Performance of Two Commercial Pregnancy‐Associated Glycoprotein Tests for Early Pregnancy Detection in Cows(Wiley, 2025-01-28) Tarik Safak; Kenan Çağrı Tümer; Yağmur İpek Alp; Taha Yasin Özen; Oznur Yilmaz‐KocThe aim of this study was to determine and compare the diagnostic accuracies of two commercial pregnancy-associated glycoprotein tests, Alertys OnFarm Pregnancy Test (AOPT) and Alertys Milk Pregnancy Test (AMPT), for early pregnancy diagnosis in dairy cattle. Holstein cows (n = 124) were used in the study. Whole blood samples were collected from the jugular vein 28 days after fixed-time artificial insemination (FTAI). In addition, teats of these cows were swabbed and milk samples were collected into sterile Falcon tubes. AOPT was performed on the farm within 2 h after whole blood collection. Milk samples for AMPT analysis were taken to the laboratory and analysed within 2 h. Transrectal ultrasonography was performed on the 32nd day after FTAI as a reference test. Comparative evaluation was made according to the AOPT and AMPT results, 28 days after FTAI. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) for the AOPT were 92.4%, 80.0%, 87.9%, 89.0% and 85.7% and for AMPT were 97.5%, 82.2%, 91.9%, 90.6% and 94.9% respectively. Cohen's kappa statistic showed a 91.9% agreement (kappa = 0.820, p < 0.001) between the reference test and AMPT, and an 87.9% agreement (kappa = 0.735, p < 0.001) between the reference test and AOPT. AOPT and AMPT offers a reliable, non-invasive (in milk) and practical approach to pregnancy diagnosis in cows. These methods enable early pregnancy detection and can be easily integrated into farm routines, enhancing reproductive management and overall herd productivity.Öğe Different essential oils can inhibit Candida albicans biofilm formation on acrylic resin by suppressing aspartic proteinase: In vitro and in silico approaches(Springer Science and Business Media LLC, 2025-01-28) Nurdan Polat Sağsöz; Leyla Güven; Bahri Gür; Canan Vejselova Sezer; Mustafa Cengiz; Figen Orhan; Özlem BarışIntroduction: Cymbopogon martini, Syzygium aromaticum, and Cupressus sempervirens are used for antimicrobial purposes in the worldwide. Both their extracts and essential oil contents are rich in active ingredients. Objective: The aim of this study was to investigate the inhibitory effect of Cymbopogon martini essential oil (CMEO), Syzygium aromaticum essential oil (SAEO) and Cupressus sempervirens essential oil (CSEO) on Candida albicans biofilm formation on heat-polymerized polymethyl methacrylate (PMMA) samples in vitro and in silico. Materials and methods: Essential oil contents with anticandidal potential were determined by Gas Chromatography-Mass Spectrometry. Following C. albicans adhesion, PMMA samples were treated independently with Corega® and each essential oil. The anticandidal activity of the essential oils was determined by spectrophotometric absorbance measurement at 600 nm, taking into account the cultures of each sample. The cytotoxicity evaluation of essential oils was performed by MTT Colorimetric assay. The software package AutoDockTools (1.5.6) was used for the in silico studies. The effect of essential oil content on the inhibition of Secreted aspartic proteinase (SAP2) was evaluated considering the Ligand@SAP2 complex formation. Results: 2% of CMEO and 5% of SAEO exhibited higher anticandidal activity than Corega® (p < 0.05), whereas Corega® had higher anticandidal activity than 2% and 5% of CSEO (p < 0.05). The cytotoxicity of essential oils on NIH/3T3 cells after 24 h was found to be 2.41 for CSEO, 2.84 for CMEO, and 2.85 µg/mL for SAEO. The results of the in silico study showed that citronellol from CMEO, chavibetol (m-eugenol) from SAEO and β-pinene from CSEO each had the highest effect on the inhibition of SAP2. The highest binding affinity value was found for citronellol at -5.3 kcal/mol. Conclusions: The biofilm formation of C. albicans onto acrylic resin was inhibited by CMEO, SAEO and CSEO at a concentration of 2% through in vitro assay. The most effective inhibition was determined to be due to citronellol in CMEO through in silico analysis.Öğe Chemical profiling and antioxidant potential of propolis from Pervari, Siirt: discovery of tannic acid and key bioactive compounds(Informa UK Limited, 2025-01-24) Erkan Sırma; Mehmet Fidan; Mesut Gök; İbrahim Tegin; Mustafa Abdullah Yılmaz; Erdal YabalakPropolis, a natural product with remarkable therapeutic potential, has gained attention for its antimicrobial, antioxidant, and anti-inflammatory properties. In this study, propolis samples from Sarıyaprak, Kovanağzı, and Çemikari in Pervari, Siirt province, were analysed comprehensively. The evaluation included wax composition, DPPH and FRAP assays, total phenolic and flavonoid content, and pollen analysis. Phytochemical compounds were identified using GC-MS and LC-MS/MS techniques. Among the regions, Çemikari samples exhibited the highest antioxidant activity and phenolic and flavonoid contents, with wax content averaging 60% across all locations. Key compounds identified via RSH-GC/MS included α-pinene, β-pinene, nonadecanal, and nonanal, while GC-MS revealed borneol, sedrenol, and benzyl alcohol. Significant phenolic compounds such as gallic acid, caffeic acid, and tannic acid (reported for the first time in Turkish propolis) were also detected. The high borneol concentration, with its strong anti-inflammatory properties, underscores the unique traits of these samples and their promising antioxidant potential for further research.
