The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Turkiye

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dc.authoridDogan, Lerzan/0000-0002-1456-4072
dc.authoridKazancioglu, Leyla/0000-0002-3833-0692
dc.authoridaydin, osman ozcan/0000-0003-4959-8982
dc.authoridYildirim, Suleyman/0000-0001-9856-3431
dc.authoridYILMAZ, BARIS/0000-0003-4811-4907
dc.authoridgultekin, hamza/0000-0001-9394-4999
dc.authoridKUCUK, Ahmet Oguzhan/0000-0002-6993-0519
dc.authoridKasapoglu, Umut Sabri/0000-0003-2869-9872
dc.authoridBoyaci Dundar, Nazlihan/0000-0003-4264-9249
dc.authoridDemir, Nalan/0000-0002-3168-9176
dc.authoridALAY, GULCIN HILAL/0000-0001-9259-9249
dc.authoridTEKIR YILMAZ, ELVAN/0000-0001-8631-2520
dc.contributor.authorGul, Fethi
dc.contributor.authorKasapoglu, Umut Sabri
dc.contributor.authorSabaz, Mehmet Suleyman
dc.contributor.authorAy, Pinar
dc.contributor.authorOktay, Burcin Doruk
dc.contributor.authorCaliskan, Gulbahar
dc.contributor.authorDemir, Nalan
dc.date.accessioned2024-12-24T19:32:52Z
dc.date.available2024-12-24T19:32:52Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear.Aims: To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19.Study Design: Multicenter prospective observational clinical study.Methods: This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged >= 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated.Results: As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 +/- 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004).Conclusion: Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients.
dc.identifier.doi10.4274/balkanmedj.galenos.2023.2023-6-90
dc.identifier.endpage444
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue6
dc.identifier.pmid37867428
dc.identifier.scopus2-s2.0-85175039964
dc.identifier.scopusqualityQ1
dc.identifier.startpage435
dc.identifier.trdizinid1254258
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2023.2023-6-90
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1254258
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7837
dc.identifier.volume40
dc.identifier.wosWOS:001094980300009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofBalkan Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.titleThe Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Turkiye
dc.typeArticle

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