Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives

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dc.authoridGumus, Selcuk/0000-0002-8628-8943
dc.authoridGumus, Aysegul/0000-0002-1613-7074
dc.authoridOkumus, Veysi/0000-0002-5505-2700
dc.contributor.authorGumus, Aysegul
dc.contributor.authorOkumus, Veysi
dc.contributor.authorGumus, Selcuk
dc.date.accessioned2024-12-24T19:33:57Z
dc.date.available2024-12-24T19:33:57Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractSchiff base derivatives with anthracene- and pyrene-based units, Al-A6 and P1-P6 were synthesized (89%-99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 mu g/mL possessed the highest metal chelating (45.8%) activity and power of reduction. In addition, P3 and A6 showed antibacterial activity against all bacteria tested and both compounds were very well bound to CT-DNA. Density functional theory method with B3LYP/6-311++ G(d,p) basis set was performed to get information about the structural and electronic properties of the present compounds. In addition, the metal coordination properties of the dimers of the parent Schiff bases were investigated through interactions with Zn2+.
dc.description.sponsorshipPresidency of Scientific Research Projects of Van Yuzuncu Yil University [FBA-2018-6825]
dc.description.sponsorshipWe are grateful to the Presidency of Scientific Research Projects of Van Yuzuncu Yil University for financial support (FBA-2018-6825).
dc.identifier.doi10.3906/kim-2005-61
dc.identifier.endpage1215
dc.identifier.issn1300-0527
dc.identifier.issue4
dc.identifier.pmid33488222
dc.identifier.scopus2-s2.0-85090967089
dc.identifier.scopusqualityQ3
dc.identifier.startpage1200
dc.identifier.trdizinid522849
dc.identifier.urihttps://doi.org/10.3906/kim-2005-61
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/522849
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8348
dc.identifier.volume44
dc.identifier.wosWOS:000560919000024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectAnthracene
dc.subjectpyrene
dc.subjectSchiff base
dc.subjectantioxidant
dc.subjectantibacterial
dc.subjectelectronic properties
dc.titleSynthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives
dc.typeArticle

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