Evaluation of salivary BDNF levels in gingivitis and periodontitis: a preliminary research

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dc.contributor.authorVeysel Tahiroglu
dc.contributor.authorEmrah Yerlikaya
dc.contributor.authorRevsa Evin Canpolat Erkan
dc.contributor.authorHasan Karagecili
dc.contributor.authorAzat Sagin
dc.contributor.authorNushet Sagin
dc.date.accessioned2025-04-16T10:25:12Z
dc.date.available2025-04-16T10:25:12Z
dc.date.issued2025-04-10
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractBackground: Oral health is closely related to physical health, life comfort, and functional needs. Gingivitis is a condition that means hardening of the gum tissue, prone to redness, swelling, or bleeding due to different reasons. Periodontitis damages the soft tissue around the teeth. It is a serious gum infection that destroys the bone that supports a person's teeth, if left untreated. BDNF is a member of the neurotrophin family, playing roles in the survival, growth, and function of neurons in the central and peripheral nervous system. This study aims to determine and compare salivary BDNF levels in individuals with periodontal disease and healthy controls, and to assess its relationship with clinical periodontal parameters. Methods: After the participants were informed and their consent was obtained, unstimulated saliva samples were taken. In our study, experimental and control groups were formed with 30 people in each group. BDNF level was measured in the saliva samples taken. Results: We found no statistically significant difference in age and gender between the healthy group, gingivitis group, and periodontitis group. There was a significant difference in the PI, GI, PPD, CAL, and BOP values in all three groups. No statistically significant difference was found when salivary BDNF levels of the groups included in the study were compared. Conclusions: Demographic and clinical findings recorded in this study support that the amount of BDNF partially affects periodontal health parameters and neurological diseases.
dc.identifier.citationTahiroglu, V., Yerlikaya, E., Erkan, R. E. C., Karagecili, H., Sagin, A., & Sagin, N. (2025). Evaluation of salivary BDNF levels in gingivitis and periodontitis: a preliminary research. BMC Oral Health, 25, 521.
dc.identifier.doi10.1186/s12903-025-05931-5
dc.identifier.issn1472-6831
dc.identifier.issue1
dc.identifier.pmid40211293
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12903-025-05931-5
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8619
dc.identifier.volume25
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.institutionauthorYerlikaya, Emrah
dc.institutionauthorid0000-0003-4050-0790
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofBMC Oral Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBDNF
dc.subjectGingivitis
dc.subjectOral health
dc.subjectPeriodontal health
dc.subjectTooth.
dc.titleEvaluation of salivary BDNF levels in gingivitis and periodontitis: a preliminary research
dc.typejournal-article
oaire.citation.issue1
oaire.citation.volume25

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