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Enzyme Inhibition Properties of Calendula officinalis, Matricaria chamomilla, and Anthemis pseudocotula: Kinetics and Molecular Docking Studies
(ACG Publications, 2025-06-15) İlhami Gülçin; Kübra Aslan; Hatice Kızıltaş; Leyla Guven; Hasan Karageçili; Doğan Arslan
This study determined the enzyme inhibition potential of three species (Calendula officinalis, Matricaria chamomilla, and Anthemis pseudocotula) from the Asteraceae family through in silico, followed by in vitro studies. Quinic acid, fumaric acid, gallic acid, chlorogenic acid, vanillic acid, quercetin, apigenin, and isorhamnetin were determined by LC-MS/MS in all of the species. Metabolic enzymes are essential catalysts regulating biochemical reactions within living organisms, facilitating energy production, detoxification, and biosynthesis. These enzymes play a crucial role in maintaining cellular homeostasis and are tightly regulated to ensure optimal metabolic function. High docking scores were also obtained for butyrylcholinesterase (BChE), α-glycosidase, α-amylase, and human carbonic anhydrase I and II enzymes (hCA I and hCA II). Among the extracts, Anthemis pseudocotula was concluded to be the best inhibitor for the enzymes, which was further determined by in vitro enzyme inhibition tests. Besides, it was concluded that all extracts showed anti-cholinergic, anti-diabetic, and anti-glaucoma properties. This is the first study determining the enzyme inhibition property of Anthemis pseudocotula and the three species' hCA I and hCA II inhibition activities.
The impact of different training methods on the hand hygiene beliefs and practices of future home caregivers: A randomized controlled trial
(Elsevier BV, 2025-06) Banu Cihan Erdoğan; Nevin Doğan; Yağmur Betül Kalle
Background: Hand hygiene is a fundamental infection control practice. Effective training methods are needed to improve students' hand hygiene beliefs and behaviors, especially for future home caregivers. Aim: This study evaluates the effects of different training methods on hand hygiene beliefs and practices of future home caregivers. Methods: A randomized controlled trial with pre-test and post-test evaluations was conducted in 2023 with first-year university students in Türkiye. Of 87 participants, 75 completed the study (video group: 25, paint demonstration: 25, soap demonstration: 25). All received theoretical training, followed by practical sessions: video demonstration, acrylic paint demonstration, or soap and water demonstration. Data was collected using demographic and knowledge forms, Hand Washing Skills Checklist, Hand Hygiene Belief Scale, and Hand Hygiene Practice Inventory. Results: All groups showed significant improvement from pre-test to post-test (p < 0.05). There was a significant difference in post-test Hand Hygiene Belief Scale mean scores among the groups; the Soap group (93.52) scored higher than the Video (90.24) and Paint (88.40) groups (H = 6.564, p = 0.038). Hand Washing Skills scores were highest in the soap group, followed by paint and video groups, but differences were not statistically significant (p > 0.05). Conclusion: Different training methods had similar effects on hand hygiene skills, though soap demonstration was more effective for beliefs. Various training approaches may be beneficial, but further research is needed to determine the most effective method.
A critical balance for health in older adults: Behavioral, normative, and control beliefs shaping fluid intake
(Informa UK Limited, 2025-06-12) Serap Canlı; Yeşim Çetinkaya Şen; Simla Adagide; Sultan Uğur
Fluid intake is influenced by intention, attitude, beliefs, and environmental factors. In this study, we examined the beliefs regarding fluid intake among women aged 65 and older, based on the Theory of Planned Behavior (TPB). We conducted qualitative research with 45 women in a nursing home in Turkey through semi-structured interviews. Our analysis revealed six themes and 21 subthemes related to fluid intake. Participants described fluid intake as beneficial and easy; however, they also mentioned barriers such as cost, health outcomes, pain, habits, and limitations. We found that doctors and family members were the main supporters, and the internet and media played a prominent role in decision-making. This study provides evidence that the Theory of Planned Behavior could be effective in explaining fluid consumption behaviors in older women. However, further research with larger samples and quantitative methods is needed to promote fluid intake.
Entomophagy Attitudes Among Turkish Generation Z University Students: A Scale Validation and Path Analysis Model for Sustainable and Healthy Dietary Choices
(Wiley, 2025-06) Emre Duman; Alev Keser
The global challenges of warming temperatures, reduced rainfall, and extreme weather events have heightened the need for sustainable food sources. With a growing world population, there is an increasing demand for environmentally sustainable food production methods, making edible insects a promising alternative due to their nutritional and ecological benefits. This study was conducted to validate the Turkish version of the Entomophagy Attitude Questionnaire (EAQ) and examine, through path analysis, the relationship between university students' attitudes toward insect consumption and sustainable, healthy eating behaviors. The sample consisted of 641 Generation Z students aged 18-23. Data were collected via the Sustainable and Healthy Eating Behaviors Scale (SHEBS), the EAQ, and a demographic survey conducted through Google Forms. Results indicated that the EAQ is a reliable and valid tool, with significant correlations among its components (p < 0.05). Among SHEBS dimensions, the "healthy and balanced diet" factor scored the highest (mean: 4.744), while the "local food" factor scored the lowest (mean: 3.361). Path analysis showed an acceptable model fit for the SHEBS dimensions on the EAQ, with "seasonal foods and avoiding food waste" showing a positive effect on the "interest" dimension of entomophagy (p < 0.05); however, no significant effect was observed for the "disgust" dimension (p > 0.05). The study suggests that public awareness should be raised to reduce negative attitudes toward entomophagy. Future studies should develop comprehensive interventions to overcome cultural barriers to entomophagy and promote this alternative to a wider audience.
Utilization of Co@CoO nanoparticles incorporated on sulphur-doped activated carbon derived from biomass waste for efficient hydrogen generation from sodium borohydride methanolysis
(Elsevier BV, 2025-10) Cafer Saka
This study explores the superior hydrogen (H2) generation performance of Co@CoO nanoparticles incorporated on sulphur-doped activated carbon derived from biomass (Co/CoO@S-doped BPAC) via the methanolysis of sodium borohydride (NaBH4). The catalyst synthesis involves the fabrication of sulphur-doped activated carbon from biomass waste, followed by the deposition of Co@CoO nanoparticles, leveraging the synergistic effect of sulphur doping and cobalt-based active sites to enhance catalytic efficiency. With S-doped BPAC and Co/CoO@S-doped BPAC, there is a very significant improvement of about 4-fold with hydrogen generation rate (HGR) of 5574 and 22,806 mL/min/gcat, respectively. The activation energy (Ea) is 27.84 kJ/mol. Analytical methods are commonly used to evaluate the structure of composites. Comprehensive structural, morphological, and surface characterizations (e.g., XRD, EDS, FTIR, SEM, TEM, XPS, BET) will be conducted to evaluate the catalyst properties. The study will systematically investigate the hydrogen generation rate, activation energy, and reusability of the catalyst under various reaction conditions, aiming for high efficiency and durability. The findings contribute to the development of high-performance, sustainable catalysts for clean H2 production. The possible reaction mechanism of this reaction with the corresponding catalyst is also elucidated.
The effect of social support perceived by parents of child burn victims on their care burden and anxiety
(Elsevier BV, 2025-08) Mehmet Emin Düken; Ayşe Arıcıoğlu Sülün; Emriye Hilal Yayan; Mürşide Zengi̇n; Tekcan Sevgi̇
Purpose: The aim of this study is to examine the effect of perceived social support on the caregiving burden and anxiety of parents of children with burn injuries. Material and methods: This is a correlational descriptive study. The study was conducted with parents of 52 children who were admitted and treated in a paediatric burn clinic at a university hospital between January and December, 2019. The Zarit Care Burden Scale, the Multidimensional Scale of Perceived Social Support, and the State Anxiety Scale were used in the study. Path analysis was performed with observed variables, and structural equation model (SEM) was constructed using Amos programme. Results: The mean age of the parents was 30.94 ± 7.33 years. In the study, the cause of burns in 55.8 % of the children was contact with flame (oil, thinner, and gas) and it was found that 82.7 % of the children had third degree burns and 65.4 % had second degree burns. A positive significant correlation was found between anxiety and caregiving burden, but a negative correlation was found between anxiety and parental social support. Conclusions: The study found that the level of anxiety and caregiving burden of parents of children with burns increased as their social support decreased. In line with the results of our study, it is seen that health professionals (doctors, nurses, psychologists, social workers) working in paediatrics can involve parents in care interventions by assessing their social support, caregiving burden, and anxiety. Practice implications: It has been observed that the care burden and anxiety levels of burned children increase as the social support they receive from their parents decreases. Healthcare professionals (doctors, nurses, psychologists, social workers) working in this clinic should provide social, emotional, and psychological support to parents and share the burden of care. It has been shown that as social support increases, caregiving and anxiety levels can improve significantly.
The effect of behavioural changes via text messaging on weight loss in women with overweight and obesity.
(2025-06-03) Duman, Emre; Tunçer, Esra; Şahin-Bodur, Gülsüm; Yılmaz, Selen; Keser, Alev
This study examined the effectiveness of short message service (SMS)-based behavioral modifications combined with nutritional education on weight loss among women with overweight and obesity. Participants were divided into a control group receiving only nutritional education and an intervention group receiving both nutritional education and daily SMS reminders for 90 days. Data collection included demographic details, health status, anthropometric measurements, and responses to the Attitude Scale for Healthy Nutrition (ASHN), the Mediterranean Diet Adherence Scale (MEDAS), and the International Physical Activity Questionnaire (IPAQ). Surveys and measurements were conducted at the start, after four weeks, and at twelve weeks. The final analysis involved 62 women, with a median age of 43 years. The intervention group had 29 participants, while the control group had 33. Results showed a significant reduction in body weight and BMI from baseline to 12 weeks. However, no significant differences in weight loss were observed between the groups. Changes in MEDAS scores varied, with an initial increase in the intervention group and a decrease in the control group. By week 12, MEDAS scores were similar in both groups. Although group differences were not statistically significant, the study highlights the potential of SMS as a motivational tool for healthy eating behaviors.
Hydrogen production and electrochemical energy storage with a dual-function application of boron and oxygen-doped biomass-based porous activated carbon-based composite material
(Elsevier BV, 2025-05) Yavuz Yardım; İlyas Genel; Cafer Saka
In this study, boron (B) and oxygen (O) atoms were doped into activated carbon (AC) derived from pomegranate peel biowaste through potassium hydroxide (KOH) activation using boric acid. This material (B, O doped ACPP) is used both as a metal-free catalyst in the production of hydrogen (H2–P) with sodium borohydride (NaBH4) in methanol (CH3OH) and as an electrode for a supercapacitor in the energy storage field. The results provide significant increases in both application areas with the same material. The TEM analysis revealed the formation of uniformly distributed nanoscale particles (∼8.25 nm), which further increases the accessible surface area and shortens ion diffusion paths. The completion time of H2 release by NaBH4 reaction in only CH3OH is 16 min. However, the H2–P reaction of NaBH4 in CH3OH with B, O doped ACPP is completed in 7 min. H2 production rate (HGR) value obtained using B, O doped ACPP with 0.25 g NaBH4 is 18471 mLmin−1gcat−1. A substantial enhancement of approximately 2.5 times in specific capacitance is observed for B, O-doped ACPP compared to ACPP. At a current density of 1.6 A g−1, the B, O-doped ACPP-GCE electrode demonstrates excellent cycling stability, 87.8 % of its capacitance after 10.000 cycles. The charge transfer resistance (Rct) values were measured to be 41.1 Ω for ACPP and 17.7 Ω for B, O doped ACPP.
Assessment of lipocalin-1, resistin, cathepsin-D, neurokinin A, agmatine, NGF, and BDNF serum levels in children with Autism Spectrum Disorder
(Walter de Gruyter GmbH, 2025-04-21) Veysel Tahiroğlu; Cüneyt Cağlayan; Ayşe Gizem Güleç; Sinem Yavuz Öztürk; Hasan Karageçili; Tahir Çağlar
Autism Spectrum Disorder (ASD) is a neurological and developmental disorder that affects all aspects of social communication, with stereotypical and limited interest and atypical responses to sensory stimuli. There isn't a reliable lab test that can help clinicians diagnose ASD. This study aimed to examine serum lipocalin-1, resistin, cathepsin-D, neurokinin A, agmatinase, brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial fibrillary acidic protein (GFAP) levels in children with ASD. The study had 40 matched control subjects and 39 ASD sufferers in total. The diagnosis was made by medical professionals using the Gilliam Autistic Disorder Rating Scale-2-TV (GOBDÖ-2-TV), Denver Developmental Screening Test, and Porteus Intelligence Tests. Compared to the control group, serum levels of lipocalin-1, resistin, cathepsin-D, agmatinase, BDNF, and NGF were found to be high and GFAP levels were low in children having ASD. B12 and magnesium levels were significantly lower in the ASD group than in the control group, while sodium and chloride levels were higher in the ASD group (p<0.05). The aforementioned parameters may be involved in the pathophysiology of ASD, as evidenced by the fact that their values were greater in children with ASD than in controls. Additionally, evaluation of some routinely measured biochemical parameters may suggest that nutritional and electrolyte balance may differ in individuals with ASD.
Evaluation of salivary BDNF levels in gingivitis and periodontitis: a preliminary research
(Springer Science and Business Media LLC, 2025-04-10) Veysel Tahiroglu; Emrah Yerlikaya; Revsa Evin Canpolat Erkan; Hasan Karagecili; Azat Sagin; Nushet Sagin
Background: Oral health is closely related to physical health, life comfort, and functional needs. Gingivitis is a condition that means hardening of the gum tissue, prone to redness, swelling, or bleeding due to different reasons. Periodontitis damages the soft tissue around the teeth. It is a serious gum infection that destroys the bone that supports a person's teeth, if left untreated. BDNF is a member of the neurotrophin family, playing roles in the survival, growth, and function of neurons in the central and peripheral nervous system. This study aims to determine and compare salivary BDNF levels in individuals with periodontal disease and healthy controls, and to assess its relationship with clinical periodontal parameters. Methods: After the participants were informed and their consent was obtained, unstimulated saliva samples were taken. In our study, experimental and control groups were formed with 30 people in each group. BDNF level was measured in the saliva samples taken. Results: We found no statistically significant difference in age and gender between the healthy group, gingivitis group, and periodontitis group. There was a significant difference in the PI, GI, PPD, CAL, and BOP values in all three groups. No statistically significant difference was found when salivary BDNF levels of the groups included in the study were compared. Conclusions: Demographic and clinical findings recorded in this study support that the amount of BDNF partially affects periodontal health parameters and neurological diseases.
Eco-friendly nanocatalysts for hydrogen generation via sodium borohydride hydrolysis and enhanced fuel cell applications
(Elsevier BV, 2025-04) Arzu Ekinci; Ömer Şahin; Sevnur Turgut; Orhan Baytar
Sodium borohydride (NaBH4) hydrolysis is a promising method for sustainable hydrogen production, but its efficiency depends on high-performance and eco-friendly catalysts. This study introduces a green hydrothermal synthesis using tobacco stem extract to fabricate Co–Sb nanoparticles, reducing toxic chemical usage compared to conventional methods. Catalytic tests confirm their high efficiency in NaBH4 hydrolysis, with hydrogen generation increasing at higher temperatures and NaOH/NaBH4 concentrations. Structural analyses (XRD, FT-IR, SEM, TEM) reveal an amorphous, porous morphology with spherical particles (∼20–30 nm). Co–Sb nanoparticles achieve a hydrogen generation rate of 5618 mlmin−1g−1, surpassing Co nanoparticles (5360 mlmin−1g−1), with lower activation energy (30.9 kJ mol−1 vs. 35.5 kJ mol−1), highlighting Co–Sb's superior catalytic efficiency—additionally, 1 wt% Sb doping enhances hydrogen production and improves PEM fuel cell performance, reaching a peak power density of 137.3 mW/cm2. However, reusability tests of the Co–Sb catalyst revealed a decline in the hydrogen generation rate, indicating catalyst deactivation due to oxidation on active surfaces and the accumulation of by-products. Furthermore, excessive Sb doping was found to block active sites on the catalyst surface, thereby reducing its efficiency. This study underscores the viability of green-synthesized Co–Sb nanoparticles for hydrogen generation and fuel cell applications, offering a sustainable alternative to energy technologies.
Bio-derived catalysts for hydrogen production: Synthesis, characterization, and performance
(Elsevier BV, 2025-03) Arzu Ekinci; Ömer Şahin; Gurbet Canpolat; Orhan Baytar
In this study, green synthesis method was used to prepare Co–La–B catalysts using Rheum ribes bark extract as stabilizing agent. SEM, EDX, XRD, FTIR, TEM and XPS analyses determined the structural and morphological properties of the Co–La–B catalyst. The average particle size was found to be about 30 nm, indicating a high surface area, which can enhance the catalytic activity. In addition, the presence of functional groups in the shell extract was confirmed, suggesting their role in stabilizing the metal particles during synthesis. The particle size was determined to be 20–50 nm in TEM analysis results. For the first time, green synthesis of Co–La–B catalyst using Rheum ribes bark extract was carried out and the effect of different NaOH/NaBH4 concentrations, different amounts of catalyst and temperature on sodium borohydride hydrolysis was studied. In the study, the cycle frequency (TOF) values for Co–La–B catalyst at different temperatures were determined to be 31610 mLH2/gcat.min. Activation energy (Ea), activation entropy (ΔS) and activation enthalpy (ΔH) values were calculated as 62.61 kJ/mol, −120 J/molK and 29.82 kJ/mol, respectively. Reusability tests determined the efficiency of the nanoparticle as 89.4 %.
Effectiveness and Acceptability of a Sexual Health Education Program for Muslim Countries: An Intervention Study
(Springer Science and Business Media LLC, 2025-03-17) Özlem Karatana; Abdullah Beyhan; Ayşe Ergün
In Muslim societies, issues related to sexual and reproductive health are rarely discussed and considered sensitive subjects. This study was conducted to assess the acceptability and effectiveness of a sexual health education program in Turkey, a Muslim country. The study was conducted using a one-group quasi-experimental design. The sexual health education program consisted of five sessions of sexual health education, pre-test, post-test, first follow-up (30 days after) and second follow-up (60 days after). The sample of the study consisted of 207 female and 79 male first year Muslim university students. At the end of the program, 96.5% of the Muslim university students stated that they liked the education, 96.2% found the education useful, 86.0% found the online education convenient, and 96.9% would use the information they learned. Muslim university students, in general, found the feasibility of the education to be highly favorable. It was determined that the post-test score of sexual health knowledge was higher than the pre-test score (p < 0.05). The program in this study was found to be adopted by Muslim university students and it is thought to be valuable in societies with similar religious beliefs and views.
Phytochemical profile and bioactive properties of sage ( Salvia fruticosa ) and thyme ( Thymus vulgaris ) extracts
(Informa UK Limited, 2025-03-19) Kübra Aslan; Emre Erden Kopar; Kader Kelle; Hasan Karageçili; Mustafa Abdullah Yilmaz; Oguz Cakir; Saleh Alwasel; Ilhami Gulcin
We examined the phytochemical content, antioxidant, antimicrobial, anticholinergic, antidiabetic, and antiglaucoma properties of ethanol and water extracts from Salvia fruticosa (SF) and Thymus vulgaris (TV). Extracts were analyzed using four antioxidant assays, while the enzyme inhibition was tested against alpha-amylase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase II (hCA II). Antimicrobial activity was evaluated against pan-resistant bacterial strains. LC-MS/MS identified rosmarinic acid as the major compound (27.61 and 34.35 mg/L in TV and SF, respectively). Ethanolic extracts had higher phenolic content (181.0 +/- 7.86 and 107.0 +/- 5.78 mu g GAE/mg for SF and TV, respectively). SF showed stronger metal-reducing capacity, while TV had superior radical scavenging ability, judging by the IC50 values (13.68 +/- 1.18 mu g/mL), defined as the concentration that reduces 50% of the enzyme activity. The highest inhibition was observed for hCA II (SF ethanolic extract, IC50 14.51 +/- 4.07 mu g/mL), AChE (SF aqueous extract, IC50 16.51 +/- 3.77 mu g/mL), and BChE (TV aqueous extract, IC50 10.60 +/- 4.93 mu g/mL). SF ethanolic extract inhibited the growth of Staphylococcus aureus and Enterococcus faecalis (11 mm at 60 mu g/mL). These findings highlight SF and TV as potential sources of natural antioxidants, enzyme inhibitors, and antimicrobials for pharmaceutical and food formulations.
Unlocking the Potential of Technology in Nursing Skills Education: A Randomized Controlled Trial
(Ataturk Universitesi, 2025-03-07) Zehra Göçmen Baykara; Nurcan Çalışkan; Deniz Ozturk; Ayişe Karadağ; Evrim Sarıtaş; Gulcan Eyuboglu; Sinan Aydoğan; Nevin Doğan; Ceyda Su Gündüz
Objective: This study aimed to determine the effect of illustrated checklists and web-access videos on nursing students' basic nursing knowledge levels and psychomotor skills. Methods: This single-blind, randomized controlled trial was conducted with 205 first-year nursing students registered in a Fundamentals of Nursing course. The students were stratified by gender and randomly assigned to the experimental and control groups using simple randomization. All students participated in theoretical lectures, demonstrations, and laboratory practices. The Intervention Group's laboratory practices were supported by illustrated checklists and web-access skill videos. Results: The intervention group's objective structured clinical exams and knowledge test scores were significantly higher than the control group's (P < .05). In total, 95.4% of the students stated that watching videos facilitated learning. Conclusion: The study found that illustrated checklists and web-accessible skill videos improved students' knowledge and skills and that the skill videos facilitated learning, increased motivation, and enhanced clinical preparation. The widespread use of illustrated checklists and web-access skill videos in nursing skills education is suggested.
Online Education on Sustainable Nutrition Affects Women's Sustainable Eating Behavior and Anthropometric Measures
(Wiley, 2025-03-12) Gülsüm Şahin‐Bodur; Esra Tunçer; Emre Duman; Selen Yilmaz; Alev Keser
Objective: To determine the effect of online sustainable nutrition education (SNE) on sustainable eating behaviors and anthropometric measurements in women. Design: In the research, a pretest-posttest quasi-experimental design was used for groups that were subjected to two different trainings. Sample: In the education group, 34 and in the control group, 51 women that between the ages of 19-50 years from six Women's Education and Culture Centers of Ankara Altındağ Municipality. Intervention: After the pretest, the Healthy Nutrition Education (HNE) group received one session of education on "healthy eating" in the second week of the study, while the SNE group received one session of education on "healthy eating" in the second week and "sustainable nutrition" in the third and fourth weeks. Participants were given SNE and its effectiveness was evaluated after 10 weeks. Results: At the end of 10 weeks, body fat percentage decreased significantly from 35.0 ± 6.7 to 33.7 ± 6.8 in the SNE group (p = 0.007). In addition, muscle mass (kg) increased significantly from 43.4[6] to 44.7[5.2] in the SNE group (p = 0.001). When covariance analysis was performed by correcting for body mass index, the group factor had an effect on body fat percentage and muscle mass (p = 0.035 and p = 0.007, respectively). After 10 weeks, the SNE group had a higher Sustainable and Healthy Eating Behaviors Scale mean score (p = 0.013), seasonal foods and avoiding food waste (p = 0.044), animal health (p = 0.003), reducing meat consumption (p = 0.022), healthy and balanced nutrition (p = 0.031), and low fat (p < 0.001) scores compared to HNE group. Conclusions: The dissemination of structured nutrition education for women is important for individuals and, thus, society to acquire and maintain positive eating practices that have an impact on physical health.
Stable electrode material for use in supercapacitor with iodine doping after sulfonation of mesoporous activated carbon particles based on microalgae biomass
(2025-01-01) Levent, Abdulkadir; Saka, Cafer
Developing appropriate electrode materials is crucial for achieving supercapacitors with high power output and extended cycle life. Among these, biomass-derived carbon electrodes hold a prominent position in supercapacitor applications. However, these electrodes need to be modified by appropriate methods to increase their performance. In this study, sulphur and iodine heteroatom functionalization was performed using a hydrothermal method on activated carbon (SPAC) derived from a microalgae precursor through potassium hydroxide activation, resulting in iodine- and sulphur-doped SPAC (iodine@S-doped SPAC). Characterization was carried out with Scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), energy-dispersive X-ray spectroscopy (EDS), and nitrogen adsorption/desorption analyses. The electrochemical properties of the resulting composite material as a supercapacitor were examined. A specific capacitance of 208.95 F/g was achieved with the iodine@S-doped SPAC supercapacitor. The maximum energy density and power density of the supercapacitor, derived from the iodine@S-doped SPAC sample, were calculated as 5.11 Wh/kg and 2000 W/kg, respectively. Additionally, the coulombic efficiency of this supercapacitor was calculated to be 87.57% at a current density of 0.06 A/g. It also exhibited a capacity retention of up to 89.72% over 1000 cycles.
Comprehensive experimental and computational analysis of endemic Allium tuncelianum: Phytochemical profiling, antimicrobial activity, and In silico studies for potential therapeutic applications
(Elsevier BV, 2025-05) Oğuzhan Özdemir; Nurten Yılmaz; Ahmad Badreddin Musatat; Tuna Demirci; Servet Çete; Emrah Yerlikaya; Mustafa Oğuzhan Kaya
Allium tuncelianum (TG), an endemic garlic species from Tunceli, Turkey, was investigated using a multidisciplinary approach combining experimental and computational methods. Density Functional Theory (DFT) calculations with B3LYP/def2-SVP/def2-TZVP basis sets were employed to analyze electronic properties, reactivity, and stability under gas and ethanol conditions. Headspace/GC-MS identified 10 major components, with diallyl disulfide (48.03 %) and 1-propene (20.72 %) as predominant. Antimicrobial assays revealed potent activity against MRSA, Salmonella paratyphi A, and E. coli, with MIC values as low as 0.063 mg/mL. Antioxidant capacity, evaluated via DPPH, metal chelating, and FRAP assays, showed promising results, with the water extract exhibiting the highest activity (1.74 mg BHT equivalent/mL). DFT and molecular docking studies highlighted key compounds as potential inhibitors of E. coli Gyrase B, with binding energies of -5.68 and -6.07 kcal/mol. ADME predictions indicated favorable drug-like properties, though some compounds showed potential CYP450 interactions and toxicity. This study provides a comprehensive understanding of TG's biochemical profile and therapeutic potential, offering insights for future research and optimization.
Utilisation of Cu2O/CuO@N, O doped catalysts on activated carbon particles derived from biological wastes for highly active hydrogen production with sodium borohydride methanolysis
(Elsevier BV, 2025-05) Cafer Saka
Despite the significant advantages of hydrogen (H2) production via sodium borohydride (SB, NaBH4) methanolysis, it is important to further develop this reaction with more efficient and cost-effective catalysts. Here, in the first stage, pomegranate peels, which are widely consumed in the world and Turkey, were evaluated in the production of activated carbon as biowaste (PPAC). In the second stage, the obtained PPAC was hydrothermally treated with nitric acid for O atom doping on the surface (O-doped PAC). In the third stage, Cu2O/CuO and N atoms particles were doped on the O-doped PPAC by hydrothermal method (Cu2O/CuO@N, O-doped PPAC). These Cu2O/CuO@N, O doped PPAC nanoparticles were used for the first time for effective H2 production from NaBH4 methanolysis(SB/ H2P). The active regions obtained based on Cu2O, CuO, N, and O particles on the carbon support exhibited HGR values of 4775 and 40622 mL/min/gcat for PPAC and Cu2O/CuO@N, O-doped PPAC, respectively. A significant increase of approximately eight times was achieved in the hydrogen generation rate (HGR) value. The XPS, EDS, and FTIR analyses successfully confirmed both CuO particles and O, N atoms doping into the PPAC structure. The activation energy for this reaction was 29.45 kJ/mol.
Green-synthesized ZrFeO nanoparticles as efficient cathode materials in PEM fuel cells
(Elsevier BV, 2025-01) Suna Tarhan; Arzu Ekinci; Orhan Baytar; Abdurrahman Akdag; Ömer Şahin
This study explores the application of ZrFeO nanoparticles, synthesized from fig leaf extract through a green synthesis method, as cathode materials for PEM fuel cells. The nanoparticles, doped with FeO and varying Zr ratios, were combined with Pt metal and characterized using XRD, SEM, EDX, and TEM to analyze their structural and morphological properties. The particle sizes for FeO and Zr-doped FeO were determined to be 2 nm and 2.5 nm, respectively. The electrochemical active surface areas of the catalysts—Pt-FeO/C and Zr-doped variants (PtFeO/C-1 wt%Zr, PtFeO/C-5 wt%Zr, and PtFeO/C-10 wt%Zr)—were measured as 97, 154, 138, and 119 m2/gPt, respectively, demonstrating a significant enhancement in surface area with the incorporation of Zr at optimal doping levels. Catalyst retention after 250 cycles was 29% for Pt–FeO/C, 60% for 1 wt% Zr-doped Pt–ZrFeO/C, 93% for 5 wt% Zr-doped Pt–ZrFeO, and 71% for 10 wt% Zr-doped Pt–ZrFeO. Performance testing at 70 °C revealed a hierarchy of catalytic activity: Pt–ZrFeO/C > Pt–FeO/C > Pt/C. The findings highlight the potential of green-synthesized ZrFeO nanoparticles as effective support materials for cathode catalysts, offering improved performance in PEM fuel cells while markedly reducing platinum dependency. This innovative approach integrates environmental sustainability with technological progress in fuel cell applications.

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