Discovery of host genetic factors through multi-locus GWAS against toxoplasmosis in sheep: addressing one health perspectives

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dc.contributor.authorYalçın Yaman
dc.contributor.authorVeysel Bay
dc.contributor.authorYiğit Emir Kişi
dc.date.accessioned2025-04-16T13:16:08Z
dc.date.available2025-04-16T13:16:08Z
dc.date.issued2025-04-12
dc.departmentFakülteler, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü
dc.description.abstractToxoplasma gondii stands as one of the most successful pathogens, capable of infecting nearly all warm-blooded species. It is estimated that up to 50% of human population might harbor Toxoplasmosis infections. One of the primary transmission routes is the consumption of tissue cysts from infected farm animals used for food production. Thus, controlling Toxoplasmosis in farm animals is of vital importance for human health and food safety. Selective breeding in farm animals, where available, could complement classical control measures like biosecurity measures, vaccination, and test-and-cull methods. This multidisciplinary approach will make the eradication of Toxoplasmosis more effective. For this purpose, we conducted four multi-locus genome-wide association (GWA) approaches to identify the polygenic factors underlying innate resistance to Toxoplasma gondii in naturally infected sheep. Our findings indicate that 16 single nucleotide polymorphisms (SNPs), exhibiting varying degrees of statistical power, play a significant role in host immunity against T. gondii infection. We propose the genes containing these SNPs or located within 100 ± Kb of them (PLSCR5, EPHA3, DGKB, IL12B, CGA, WDR64, TMEM158, CLMP, and SIAE) as potential candidate genes. This study represents the first exploration of host genetic factors against Toxoplasmosis in livestock, utilizing the ovine paradigm as its foundation.
dc.identifier.citationYaman, Y., Bay, V., & Kişi, Y. E. (2025). Discovery of host genetic factors through multi-locus GWAS against toxoplasmosis in sheep: addressing one health perspectives. BMC Veterinary Research, 21(1), 1-16.
dc.identifier.doi10.1186/s12917-025-04719-7
dc.identifier.issn1746-6148
dc.identifier.issue1
dc.identifier.pmid40221787
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s12917-025-04719-7
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8621
dc.identifier.volume21
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.institutionauthorYaman, Yalçın
dc.institutionauthorid0000-0003-2705-2831
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofBMC Veterinary Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGenetic resistance
dc.subjectHost immunity
dc.subjectMulti-locus GWAS
dc.subjectPublic health
dc.subjectSheep
dc.subjectToxoplasmosis.
dc.titleDiscovery of host genetic factors through multi-locus GWAS against toxoplasmosis in sheep: addressing one health perspectives
dc.typejournal-article
oaire.citation.issue1
oaire.citation.volume21

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