Examination of Changes in Enzyme Activities of Erythrocyte Glucose 6-Phosphate Dehydrogenase and 6-Phosphogluconate Dehydrogenase in Rats Given Naringenin and Lead Acetate

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dc.contributor.authorDemirdag, Ramazan
dc.contributor.authorComakli, Veysel
dc.contributor.authorOzkaya, Ahmet
dc.contributor.authorSahin, Zafer
dc.contributor.authorDag, Uzeyir
dc.contributor.authorYerlikaya, Emrah
dc.contributor.authorKuzu, Muslum
dc.date.accessioned2019-11-18T10:44:23Z
dc.date.available2019-11-18T10:44:23Z
dc.date.issued2015
dc.departmentBelirleneceken_US
dc.description.abstractIn our study, controlled experimental groups were performed by giving substances Lead acetate, Naringenin andNaringenin+Lead acetate to rats in vivo conditions Changes in the glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) enzyme activities in erythrocytes of rats in these groups were compared to the Control group. An inhibition significant degree for G6PD enzyme activity was observed in all groups when compared to the Control group (p < 0.001). While inhibition significant degree for 6PGD enzyme activity was observed in Lead acetate groups (p < 0.001), no significant effect was observed in the Naringenin and Naringenin + Lead acetate groups (p > 0.05). In addition, lead levels in the groups of rats were determined using an inductively coupled plasma mass spectrometer (ICP-MS) device. As a result of measurements by the ICP-MS device, lead levels were found as an average of 42.9 ± 2.51, 36.71 ± 1.13, 172.16 ± 9.63, and 95.07 ± 5.87 ppm in the Control, Naringenin, Lead acetate and Naringenin+Lead acetate groups, respectively. Our results were shown thatNaringenin has protective effects on the Lead acetate induced oxidative stress erythrocytes in rat.en_US
dc.identifier.pmid25228019
dc.identifier.scopus2-s2.0-84920511669
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12604/1617
dc.identifier.wosWOS:000347540200006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.publicationcategoryUlusal Hakemli Dergi Makalesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKG_20241224
dc.subjectMetal; Naringenin; Glucose 6-Phosphate Dehydrogenase; 6-Phosphogluconate Dehydrogenase;en_US
dc.titleExamination of Changes in Enzyme Activities of Erythrocyte Glucose 6-Phosphate Dehydrogenase and 6-Phosphogluconate Dehydrogenase in Rats Given Naringenin and Lead Acetateen_US
dc.typeArticleen_US

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