Protective effects of ellagic acid in D-galactosamine-induced kidney damage in rats

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dc.contributor.authorAyhanci, Adnan
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorKutlu, Hatice Mehtap
dc.contributor.authorVejselova, Djanan
dc.date.accessioned2017-05-17T11:36:49Z
dc.date.available2017-05-17T11:36:49Z
dc.date.issued2016-12-12
dc.departmentBelirleneceken_US
dc.description.abstractD-Galactosamine (D-GalN), which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D-GalN intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. We have investigated both preventive and curative effects of ellagic acid (EA) in this study. EA treatment at a gavage dose of 20 mg/kg body weight was administered before and after intraperitoneal (i.p.) injection of D-GalN at a dose of 750 mg/kg. Tissue and blood samples of animals were collected for morphological and biochemical evaluations. Our study results suggest that EA treatment both prior to and after the toxin administration successfully altered the toxic effects on the rats. Moreover, pre-treatment of EA was more protective than post-treatment indicated by histopathological and biochemical values. In conclusion, EA treatment both before and after D-GalN intoxication could protect kidney tissues against D-GalN induced oxidative stress.en_US
dc.identifier.pmid26660314
dc.identifier.scopus2-s2.0-84949673834
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/20.500.12604/679
dc.identifier.wosWOS:000383495000009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergi Makalesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKG_20241224
dc.subjectD-GalNen_US
dc.subjectEllagic aciden_US
dc.subjectApoptotic markersen_US
dc.subjectRenal failureen_US
dc.titleProtective effects of ellagic acid in D-galactosamine-induced kidney damage in ratsen_US
dc.typeArticleen_US

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