Accurate and simple determination of oxcarbazepine in human plasma and urine samples using switchable-hydrophilicity solvent in GC-MS

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dc.authoridBorklu budak, Turkan/0000-0002-1294-2682
dc.authoridBodur, Suleyman/0000-0002-2994-9047
dc.authoridERULAS, FATIH AHMET/0000-0002-3506-6881
dc.authoridCHORMEY, DOTSE SELALI/0000-0002-7412-7800
dc.contributor.authorErarpat, Sezin
dc.contributor.authorBodur, Suleyman
dc.contributor.authorAyyildiz, Merve Firat
dc.contributor.authorGunkara, Omer Tahir
dc.contributor.authorErulas, Fatih
dc.contributor.authorChormey, Dotse Selali
dc.contributor.authorTurak, Fatma
dc.date.accessioned2024-12-24T19:24:08Z
dc.date.available2024-12-24T19:24:08Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractThis work presents a sensitive and rapid analytical method for the determination of oxcarbazepine in human plasma and urine samples. A vortex-assisted switchable hydrophilicity solvent-based liquid phase microextraction (VA-SHS-LPME) was used to preconcentrate oxcarbazepine from the samples before the determination by gas chromatography mass spectrometry. The switchable hydrophilicity solvent was synthesized by protonatingN,N-dimethylbenzylamine with carbon dioxide to make it totally miscible with an equivalent volume of water. Parameters of the VA-SHS-LPME method including volume of switchable hydrophilicity solvent, concentration/volume of sodium hydroxide and vortex period were systematically optimized. Under the optimum conditions, good linearity ranging from 27.03 to 353.47 mu g/kg was obtained for the analyte. Limit of detection and quantitation values were found to be 6.2 and 21 mu g/kg (mass base), respectively. The relative standard deviation was calculated as 6.9% for six replicate measurements of the lowest concentration of the calibration plot. Satisfactory recovery results were calculated in the range of 97-100% for human plasma and urine samples spiked at five different concentrations.
dc.description.sponsorshipYildiz Technical University Scientific Research Project [FBA2019-3530]
dc.description.sponsorshipYildiz Technical University Scientific Research Project, Grant/Award Number: FBA2019-3530
dc.identifier.doi10.1002/bmc.4915
dc.identifier.issn0269-3879
dc.identifier.issn1099-0801
dc.identifier.issue10
dc.identifier.pmid32529647
dc.identifier.scopus2-s2.0-85087152306
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/bmc.4915
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5847
dc.identifier.volume34
dc.identifier.wosWOS:000548918900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBiomedical Chromatography
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectgas chromatography-mass spectrometry
dc.subjecthuman plasma
dc.subjectoxcarbazepine
dc.subjectswitchable hydrophilicity solvent
dc.subjecturine
dc.titleAccurate and simple determination of oxcarbazepine in human plasma and urine samples using switchable-hydrophilicity solvent in GC-MS
dc.typeArticle

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