Evaluation of miRNA Profile and Its Relationship with Metabolic Disorders in Obese and Pre-Obese Patients

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dc.contributor.authorKürşat Kargün
dc.contributor.authorErhan Aygen
dc.contributor.authorMehmet Fatih Ebiloğlu
dc.contributor.authorNaci Ömer Alayunt
dc.contributor.authorLütfiye Kadıoğlu Dalkılıç
dc.date.accessioned2025-05-12T12:14:33Z
dc.date.available2025-05-12T12:14:33Z
dc.date.issued2025-04-17
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObesity is a growing global public health concern, with its prevalence rapidly increasing in Turkey, leading to severe consequences. Genetic factors, particularly mutations in structural genes and microRNAs (miRNAs) involved in gene expression regulation have been widely investigated in obesity research. This study aimed to explore the role of obesity-associated miRNAs and their potential interaction with vascular response alterations. A total of 60 obese and pre-obese patients and 26 age- and sex-matched healthy controls from the General Surgery Department of Fırat University Medicine School were included. The expression levels of 93 miRNAs were analyzed in 86 samples using the Fluidigm Biomark RT-PCR system, with 5S RNA as the housekeeping gene. Significant differences were observed in weight, BMI, cholesterol, triglyceride levels, and lymphocyte counts between the groups (p < 0.0001). Several miRNAs, including hsa-miR-148a-3p, hsa-miR-503-3p, hsa-miR-34a-5p, and hsa-miR-199a-3p, were significantly downregulated in obese patients. Additionally, gender-specific differences in miRNA expression were identified. These findings indicate that miRNAs play a crucial role in obesity pathophysiology and could serve as potential biomarkers and therapeutic targets for obesity treatment.
dc.identifier.citationKargün, K., Aygen, E., Ebiloğlu, M. F., Alayunt, N. Ö., & Dalkılıç, L. K. (2025). Evaluation of miRNA Profile and Its Relationship with Metabolic Disorders in Obese and Pre-Obese Patients. Current Issues in Molecular Biology, 47(4), 280.
dc.identifier.doi10.3390/cimb47040280
dc.identifier.issn1467-3045
dc.identifier.issue4
dc.identifier.scopus2-s2.0-105003595953
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.3390/cimb47040280
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8652
dc.identifier.volume47
dc.identifier.wos001475727700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAlayunt, Naci Ömer
dc.institutionauthorid0000-0003-2215-0934
dc.publisherMDPI AG
dc.relation.ispartofCurrent Issues in Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfludeim
dc.subjectmiRNA
dc.subjectobese
dc.subjectpre-obese
dc.titleEvaluation of miRNA Profile and Its Relationship with Metabolic Disorders in Obese and Pre-Obese Patients
dc.typejournal-article
oaire.citation.issue4
oaire.citation.volume47

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