The acute effects of simulated hypoxic training at different altitudes on oxidative stress and muscle damage in elite long-distance runners

Basit Öğe Kaydı
dc.contributor.authorMücahit Sarikaya
dc.contributor.authorBeyza Öğe
dc.contributor.authorNuri Mert Embiyaoğlu
dc.contributor.authorMuzaffer Selçuk
dc.contributor.authorVedat Çınar
dc.contributor.authorSalih Öner
dc.contributor.authorYıldırım Gökhan Gencer
dc.contributor.authorMehdi Aslan
dc.contributor.authorMustafa Sencer Ulema
dc.contributor.authorYunus Emre Yarayan
dc.contributor.authorKadir Keskin
dc.contributor.authorNouf H. Alkhamees
dc.contributor.authorBodor Bin Sheeha
dc.contributor.authorGerasimos V. Grivas
dc.contributor.authorSameer Badri AL-Mhanna
dc.contributor.authorAlexios Batrakoulis
dc.date.accessioned2025-05-21T06:57:01Z
dc.date.available2025-05-21T06:57:01Z
dc.date.issued2025-05-12
dc.departmentYüksekokullar, Beden Eğitimi ve Spor Yüksekokulu, Antrenörlük Eğitimi Bölümü
dc.description.abstractBackground: Understanding the impact of altitude on muscle damage and oxidative stress is essential for optimizing training and recovery strategies for athletes exposed to high-altitude conditions. Therefore, this study aimed to investigate the effects of acute exercise at different altitudes on oxidative stress and muscle damage. Methods: A total of twelve elite long-distance runners (mean age: 20.3 ± 1.5 years) from different branches participated in the study. The exercise protocol was the Bruce submaximal treadmill exercise test, which was conducted under three simulated hypoxic conditions (at 1,700 m, 2,450 m, and 3,200 m) and one normoxic condition (sea level). All measurements took place at the same time of the day. After the exercise protocol, 5 ml venous blood samples were taken from the participants, while heart rate and oxygen saturation were monitored at the 3rd, 6th, 9th, and 12th minutes during the exercise. Results: Significant altitude-dependent variations were observed in oxidative stress markers, with total oxidant status (TOS) (p = 0.017) and malondialdehyde (MDA) (p < 0.001) levels increasing at higher altitudes, while total antioxidant status (TAS) (p < 0.001) exhibited an elevation and oxidative stress index (OSI) (p < 0.001) demonstrated a decline as altitude increased. However, no significant difference was found in creatine kinase (CK, p = 0.059) levels. Additionally, there were significant differences in the oxygen saturation measurement taken at the 3rd (p < 0.001), 6th (p < 0.001), 9th (p < 0.001), and 12th (p < 0.001), minutes following the exercise session. There was no difference in the pulse measurement taken at the 3rd and 12th minutes, but a difference was observed at the 6th and 9th minutes post-exercise (p < 0.01). Conclusions: In conclusion, the study determined that endurance exercises performed under simulated normobaric hypoxia at different altitudes increased TAS and reduced OSI in elite long-distance runners. The increase in TAS and the reduction in OSI were more pronounced at higher altitudes, particularly at 2,450 m and 3,200 m, compared to sea level. These findings highlight the need for altitude-specific training and recovery strategies to minimize oxidative stress and muscle damage in athletes.
dc.identifier.citationSarikaya, M., Öğe, B., Embiyaoğlu, N. M., Selçuk, M., Çınar, V., Öner, S., ... & Batrakoulis, A. (2025). The acute effects of simulated hypoxic training at different altitudes on oxidative stress and muscle damage in elite long-distance runners. PeerJ, 13, e19338.
dc.identifier.doi10.7717/peerj.19338
dc.identifier.issn2167-8359
dc.identifier.pmid40376560
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.7717/peerj.19338
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8670
dc.identifier.volume12
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.institutionauthorAslan, Mehdi
dc.institutionauthorid0000-0001-6711-684X
dc.language.isoen
dc.publisherPeerJ
dc.relation.ispartofPeerJ
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAltitude
dc.subjectHypoxia
dc.subjectMuscle damage
dc.subjectOxidative stress
dc.subjectTraining
dc.titleThe acute effects of simulated hypoxic training at different altitudes on oxidative stress and muscle damage in elite long-distance runners
dc.typejournal-article
oaire.citation.volume13

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Mehdi-Aslan-2025.pdf
Boyut:
1.39 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayın Koleksiyonu
2) Makale
Scopus İndeksli Yayınlar Koleksiyonu
WOS İndeksli Yayınlar Koleksiyonu