Antioxidant properties of Ferulago angulata and its hepatoprotective effect against N-nitrosodimethylamine-induced oxidative stress in rats

dc.authoridYILDIRIM, Serkan/0000-0003-2457-3367
dc.authoridBayramoglu AKKOYUN, Mahire/0000-0001-5150-5402
dc.authoridOZGOKCE, FEVZI/0000-0002-3119-8561
dc.authoridEkin, Suat/0000-0002-6502-5028
dc.contributor.authorKiziltas, Hatice
dc.contributor.authorEkin, Suat
dc.contributor.authorBayramoglu, Mahire
dc.contributor.authorAkbas, Esvet
dc.contributor.authorOto, Gokhan
dc.contributor.authorYildirim, Serkan
dc.contributor.authorOzgokce, Fevzi
dc.date.accessioned2024-12-24T19:28:18Z
dc.date.available2024-12-24T19:28:18Z
dc.date.issued2017
dc.departmentSiirt Üniversitesi
dc.description.abstractContext: Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds. Objective: This study determines antioxidant properties of FASB flowers, the levels of minerals and vitamins, and also, evaluates the hepatoprotective effect of flowers against N-nitrosodimethylamine (NDMA) induced on liver tissue by assessing antioxidant enzymes and histopathological parameters in Wistar albino rats. Materials and methods: In the study, the rats were divided into six groups of ten. Control, untreated animals were given 0.9% NaCl. Rats were intraperitoneally given NDMA (10 mg/kg) for the first 7 days. FASB methanol extract (150 and 300 mg/kg) was administered orally for 21 days. Results: a-Tocopherol, retinol, ascorbic acid, total antioxidant activity, phenolic and flavonoid contents of FASB were 0.70 +/- 0.13, 0.29 +/- 0.03 mu g/g, 139.32 +/- 7.06 mu g/100 g, 171.61 +/- 6.05 mM ascorbic acid/g, 90.47 +/- 4.11 mg GA/g and 37.39 +/- 2.85 mg QE/g. DPPH and hydroxyl radical scavenging activity was obtained IC 50 67.34 +/- 4.14 and 64.87 +/- 4.68 mu g/mL, respectively. Discussion and conclusion: The results of the study indicated that FASB flowers contain high levels of vitamins, minerals, total antioxidant activity, phenolics and flavonoids. Due to the positive effect on significant changes in antioxidant enzymes of liver tissue and histopathological examination, it is thought that the plant could be used as a hepatoprotective.
dc.description.sponsorshipScientific Research Projects Presidency of Yuzuncu Yil University [2013-FBE-D009]
dc.description.sponsorshipThe study was supported by a grant from the Scientific Research Projects Presidency of Yuzuncu Yil University [2013-FBE-D009].
dc.identifier.doi10.1080/13880209.2016.1270974
dc.identifier.endpage897
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue1
dc.identifier.pmid28142310
dc.identifier.scopus2-s2.0-85015105118
dc.identifier.scopusqualityQ1
dc.identifier.startpage888
dc.identifier.urihttps://doi.org/10.1080/13880209.2016.1270974
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7009
dc.identifier.volume55
dc.identifier.wosWOS:000395131900017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPharmaceutical Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectFerulago angulata
dc.subjectAntioxidant capacity
dc.subjectSOD
dc.subjectGSH-Px
dc.subjectCAT
dc.titleAntioxidant properties of Ferulago angulata and its hepatoprotective effect against N-nitrosodimethylamine-induced oxidative stress in rats
dc.typeArticle

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