Inhibition Effects of Some Non-Proteinogenic Amino Acid Derivatives on Carbonic Anhydrase Isoenzymes and Acetylcholinesterase: An In Vitro Inhibition and Molecular Modeling Studies

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dc.contributor.authorAlim, Zuhal
dc.contributor.authorRawat, Ravi
dc.contributor.authorAdem, Sevki
dc.contributor.authorEyuepoglu, Volkan
dc.contributor.authorAkkemik, Ebru
dc.date.accessioned2024-12-24T19:24:08Z
dc.date.available2024-12-24T19:24:08Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractAmino acid derivatives are molecules of interest for medicinal chemistry and drug design studies due to their important chemical properties. In this study, the inhibition effects of some non-proteinogenic amino acid derivatives (hippuric acid (A), N-(9-Fluorenylmethoxycarbonyl)-D-valine (B), N-Z-(1-Benzotriazolylcarbonyl) methylamine (C), (S)-N-Z-1-Benzotriazolylcarbonyl-2-phenylethylamine (D)) on carbonic anhydrase I (hCA-I), II (hCA-II) isoenzymes and acetylcholinesterase (AChE) activity, whose inhibitors are of vital pharmacological importance, were examined. While carbonic anhydrase (CA) inhibitors are effective molecule candidates for the treatment of many diseases from glaucoma to cancer, acetylcholinesterase inhibitors are target molecules for the treatment of Alzheimer ' s disease. According to the results of this study, compound D had a strong inhibitory effect on hCA-I (IC50: 0.836 mu M) and hCA-II (IC50: 0.661 mu M), while compound B (IC50: 100 mu M) showed a strong inhibitory effect on AChE activity. In addition, inhibition results were supported by molecular modeling studies. We hope that the obtained results will contribute to the synthesis of new and effective amino acid derivative inhibitors for CA and AChE.
dc.description.sponsorshipAhi Evran University [004]
dc.description.sponsorshipThe authors thank to Ahi Evran University Research Fund Accounting for their support to carry out this work (Project number: FEF. A4. 22. 004).
dc.identifier.doi10.1002/cbdv.202401225
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmid39183452
dc.identifier.scopus2-s2.0-85206891523
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/cbdv.202401225
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5851
dc.identifier.wosWOS:001338024000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectAmino acids
dc.subjectCarbonic anhydrase
dc.subjectAcetylcholinesterase
dc.subjectEnzyme inhibition
dc.subjectMolecular docking
dc.titleInhibition Effects of Some Non-Proteinogenic Amino Acid Derivatives on Carbonic Anhydrase Isoenzymes and Acetylcholinesterase: An In Vitro Inhibition and Molecular Modeling Studies
dc.typeArticle

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