Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron

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dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.authoridCETIK YILDIZ, Songul/0000-0002-7855-5343
dc.authoridBilici, Namik/0000-0002-8747-4713
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorSahinturk, Varol
dc.contributor.authorYildiz, Songul Cetik
dc.contributor.authorSahin, Ilknur Kulcanay
dc.contributor.authorBilici, Namik
dc.contributor.authorYaman, Suzan Onur
dc.contributor.authorAltuner, Yilmaz
dc.date.accessioned2024-12-24T19:27:28Z
dc.date.available2024-12-24T19:27:28Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground: Cyclophosphamide (CP) is an alkylating chemotherapeutic drug used in the treatment of many types of cancer. However, as with other chemotherapeutic drugs, the use of CP is limited by the damage to healthy tissues such as testes, bladder and liver as well as cancerous tissue. Boron (B) is a trace element with many biological properties such as antioxidant, anti-apoptotic and anti-lipid per oxidation. Methods: This current study aims to determine protective effects of B on CP induced testicular toxicity. The rats were divided into 4 groups (control, CP, B and B plus CP groups). The testes of experimental animals were taken for histological, apoptotic markers and biochemical analysis. Results: The damage to some seminifer tubules, loss of typical appearance, thinning of seminifer epithelium and relative enlargement of the tubule lumen were watched in testis of the group that administrated CP. Moreover, Bcl-2, TAC and GSH levels decreased while TOC, OSI, MDA, Bax and Caspase-3 levels increased. On the other hand, pretreatment limited to B in the B plus CP group, testicular tissue improved. In addition, Bcl-2, GSH, TAC levels increased, Bax, MDA, TOC, OSI and caspase-3 levels decreased. Conclusion: B significantly reduced testicular lipid per-oxidation and strengthened antioxidant defenses. Our results showed that pre-treatment B can protect rat testis against CP-induced testicular damage owing to its anti-lipid per oxidation, anti-oxidant and anti-apoptotic properties.
dc.identifier.doi10.1016/j.jtemb.2020.126574
dc.identifier.issn0946-672X
dc.identifier.issn1878-3252
dc.identifier.pmid32516632
dc.identifier.scopus2-s2.0-85085993113
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2020.126574
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6644
dc.identifier.volume62
dc.identifier.wosWOS:000586028000015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofJournal of Trace Elements in Medicine and Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectCyclophosphamide
dc.subjectTesticular damage
dc.subjectApoptosis
dc.subjectBoron
dc.subjectAnti-Oxidant
dc.subjectLipid per oxidation
dc.titleCyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron
dc.typeArticle

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