A Significant Need in the Medical Field: A New Method for Putrescine, Spermine and Spermidine Using High-Performance Liquid Chromatography (HPLC)

Basit Öğe Kaydı
dc.contributor.authorNaci Ömer Alayunt
dc.date.accessioned2025-05-13T06:08:46Z
dc.date.available2025-05-13T06:08:46Z
dc.date.issued2025-03-21
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractThe analysis of polyamines such as putrescine, spermine, and spermidine is very important for the diagnosis and treatment of various diseases, especially in the field of medicine and health. However, HPLC analysis methods are very limited in the literature. This study is very important in terms of validation parameters such as the linearity, reproducibility, and standard operating curves of polyamines such as serum putrescine, spermine and spermidine. Therefore, we developed a modified method for the analysis of serum putrescine, spermine, and spermidine. This study is superior to indirect measurement methods and is important as a gold standard. In this study, a reproducible method was developed according to the standard putrescine, spermine, and spermidine working curves and other validation criteria for HPLC. Polyamine biosynthesis is an ancient metabolic pathway found in all living organisms and the homeostasis of polyamines is essential for cell survival. This new HPLC method is a first in the field of medicine in that it provides fast, accurate, and reliable results in serum putrescine, spermine, and spermidine analysis and is used in routine analyses in the diagnosis of some specific diseases.
dc.identifier.citationÖmer, A. N. (2025). A Significant Need in the Medical Field: A New Method for Putrescine, Spermine and Spermidine Using High-Performance Liquid Chromatography (HPLC). Processes, 13(4), 941.
dc.identifier.doi10.3390/pr13040941
dc.identifier.issn2227-9717
dc.identifier.issue4
dc.identifier.scopus2-s2.0-105003796363
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.3390/pr13040941
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8655
dc.identifier.volume13
dc.identifier.wos001474575200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAlayunt, Naci Ömer
dc.institutionauthorid0000-0003-2215-0934
dc.language.isoen
dc.publisherMDPI AG
dc.relation.ispartofProcesses
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHPLC
dc.subjectputrescine
dc.subjectserum
dc.subjectspermidine
dc.subjectspermine
dc.titleA Significant Need in the Medical Field: A New Method for Putrescine, Spermine and Spermidine Using High-Performance Liquid Chromatography (HPLC)
dc.typejournal-article
oaire.citation.issue4
oaire.citation.volume13

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Naci Ömer-Alayunt-2025.pdf
Boyut:
1.48 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
2-Makale
WOS İndeksli Yayınlar Koleksiyonu