Nephroprotective effect of ferulic acid on gentamicin-induced nephrotoxicity in female rats

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dc.contributor.authorErseckin, Vasfiye
dc.contributor.authorMert, Handan
dc.contributor.authorIrak, Kivanc
dc.contributor.authorYildirim, Serkan
dc.contributor.authorMert, Nihat
dc.date.accessioned2024-12-24T19:28:03Z
dc.date.available2024-12-24T19:28:03Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractFerulic acid is a kind of phenolic compound that can be found in various fruits and vegetables. This study aims to investigate the effect of ferulic acid on nephrotoxicity induced by gentamicin (GM). In this study, rats were separated into 4 groups such that each containing 8 randomly selected rats: Control group, Ferulic Acid (FA) group, Gentamicin (GM) group and Gentamicin + Ferulic acid (GM + FA) group. Blood samples were collected after 24 hours following the 8-day trial period, and kidneys were taken out for histopathological evaluation. Serum urea, creatinine, uric acid and LDH analyses were performed in autoanalyzer while Malondialdehyde (MDA), Advanced Oxidized Protein Products (AOPP), Glutathione (GSH), Superoxide dismutase (SOD), Catalase (CAT), Interleukin 6 (IL-6), Tumor Necrosis Factor-alpha (TNF-alpha) analyses were performed in ELISA, and kidney tissues were also examined histopathologically. Urea (p < .001), creatinine (p < .001), MDA (p < .01), AOPP (p < .001), IL-6 (p < .01) and TNF-alpha (p < .001) levels were found to be statistically and significantly lowered in GM + FA group when compared to GM group. As a result, ferulic acid has reduced the inflammation in nephrotoxicity induced by GM, causing decreased oxidative stress. In this study, anti-inflammatory features of ferulic acid have come to the forefront rather than the antioxidant features. It can be said that ferulic acid reduces nephrotoxic damage and has protective properties for kidneys.
dc.description.sponsorship[TYL-2018-6991]
dc.description.sponsorshipThis manuscript is produced from Master Thesis titled Investigation of the effect of ferulic acid on gentamicin-induced nephrotoxicity in rats studied by Vasfiye Erseckin on 27/06/2019. We would like to thank to Van YYU Directory of Scientific Research Project Unit who supported to this thesis project (Project Number: TYL-2018-6991).
dc.identifier.doi10.1080/01480545.2020.1759620
dc.identifier.endpage669
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue2
dc.identifier.pmid32354291
dc.identifier.scopus2-s2.0-85084270498
dc.identifier.scopusqualityQ1
dc.identifier.startpage663
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1759620
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6903
dc.identifier.volume45
dc.identifier.wosWOS:000532128300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectFerulic acid
dc.subjectgentamicin
dc.subjectnephrotoxicity
dc.subjectoxidative stress
dc.subjectcytokine
dc.titleNephroprotective effect of ferulic acid on gentamicin-induced nephrotoxicity in female rats
dc.typeArticle

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