Evaluation of tumor-suppressive properties and apoptotic functions of Mad Honey and Vincristine applications in a rat model of breast cancer

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dc.authoridGulendag, Erman/0000-0002-3335-7247
dc.contributor.authorKurtdede, Efe
dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorAlperen, Ahmet Mahmut
dc.contributor.authorBaran, Berk
dc.contributor.authorKuzu, Necat
dc.contributor.authorGulendag, Erman
dc.date.accessioned2024-12-24T19:33:49Z
dc.date.available2024-12-24T19:33:49Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, the suppressive effects of vincristine and Turkish mad honey alone and in co-applications were biochemically, hematologically, and histopathologically investigated in a mammary tumor model induced with 7,12-dimethylbenz[a]anthracene (DMBA) in rats. A total of 72 rats, 43-49 days old, were divided into 6 groups of 12 rats each. The control group (CG) consisted of healthy rats. The vehicle group (VG) received only vehicle substance and the cancer control group (CCG) was given only DMBA. DMBA and the honey group (HG) given group. DMBA and the vincristine (VinG) given group, and DMBA, the vincristine-honey group (VHG) received both Turkish mad honey and vincristine. Turkish mad honey and/or vincristine was given in the last 4 weeks of the 13-week trial period. White blood cell and lymphocyte counts differed significantly in the CCG and VG groups. Alanine transaminase and total protein levels were higher in the CCG and VinG groups. Aspartate transaminase was higher in the CCG, HG and VG groups. Caspase-3 and Bax protein levels were in the HG and VHG groups significantly higher than CCG. In caspase-8 protein level VHG significantly higher than other groups. Caspase-9 protein level was in CG and VG groups significantly lower than other groups. Bcl-xL increased more in the CCG group. Anaplasia was reduced in the HG and VinG groups, although apoptosis and other cellular damages increased. It was concluded that mad honey and vincristine could be considered together as effective therapeutic agents in this model of DMBA-induced breast cancer.
dc.description.sponsorshipAnkara University Scientific Research [21B0239002]
dc.description.sponsorshipThis study was supported by Ankara University Scientific Research Grant No: 21B0239002.
dc.identifier.doi10.33988/auvfd.1281608
dc.identifier.endpage302
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85201684102
dc.identifier.scopusqualityQ3
dc.identifier.startpage291
dc.identifier.trdizinid1249212
dc.identifier.urihttps://doi.org/10.33988/auvfd.1281608
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1249212
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8307
dc.identifier.volume71
dc.identifier.wosWOS:001267858900003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectApoptosis
dc.subjectBreast Cancer
dc.subjectRat
dc.subjectTurkish Mad Honey
dc.titleEvaluation of tumor-suppressive properties and apoptotic functions of Mad Honey and Vincristine applications in a rat model of breast cancer
dc.typeArticle

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