Investigation of the protective effect of ellagic acid for preventing kidney injury in rats exposed to nicotine during the fetal period

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dc.authoridKaradeniz, Ali/0000-0002-0976-9380
dc.contributor.authorAkkoyun, H. T.
dc.contributor.authorKaradeniz, A.
dc.date.accessioned2024-12-24T19:30:59Z
dc.date.available2024-12-24T19:30:59Z
dc.date.issued2016
dc.departmentSiirt Üniversitesi
dc.description.abstractWe investigated the possible protective effects of ellagic acid on rat kidneys exposed to nicotine during the fetal period. Twenty pregnant female rats were divided randomly into four groups: control (C), nicotine (N), ellagic acid (EA) and nicotine + ellagic acid (N + EA). Nicotine and ellagic acid treatments were continued throughout the pregnancies and for 15 days after delivery. On day 15, all neonatal pups were sacrificed and their kidneys were removed for biochemical and histopathological examination. The nicotine treatment significantly decreased body weight, total glutathione (GSH), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities, and increased malondialdehyde (MDA) and nitric oxide (NO) levels in the N group compared to controls. EA treatment ameliorated decreased body weight, GSH, GSH-Px and SOD activities, and increased MDA and NO levels in group N + EA compared to group N (p < 0.05). Nicotine caused kidney damage as shown by incomplete development of glomeruli and Bowman's capsules. Nicotine also caused greater apoptosis in group N compared to group C. Ellagic acid treatment produced histological kidney structure that was closer to normal and it exerted an anti-apoptotic effect in the N + EA group compared to the N group. EA played a protective role against nicotine-induced nephrotoxicity and oxidative stress in rats owing to its antioxidant, radical scavenging and anti-apoptotic effects.
dc.identifier.doi10.3109/10520295.2015.1078910
dc.identifier.endpage115
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2
dc.identifier.pmid26529089
dc.identifier.scopus2-s2.0-84955389214
dc.identifier.scopusqualityQ2
dc.identifier.startpage108
dc.identifier.urihttps://doi.org/10.3109/10520295.2015.1078910
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7754
dc.identifier.volume91
dc.identifier.wosWOS:000368552800005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectellagic
dc.subjectacid
dc.subjectfetal damage
dc.subjectkidney
dc.subjectnicotine
dc.subjectrat
dc.titleInvestigation of the protective effect of ellagic acid for preventing kidney injury in rats exposed to nicotine during the fetal period
dc.typeArticle

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