Effect of Xylazine on Pharmacokinetics and Physiological Efficacy of Intravenous Carprofen in Castrated Goats Kids

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dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.authoridTURK, ERDINC/0000-0003-1735-1774
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridDingil, Hasan Basri/0000-0001-5212-4804
dc.contributor.authorUney, Kamil
dc.contributor.authorYuksel, Murat
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorCoskun, Devran
dc.contributor.authorTurk, Erdinc
dc.contributor.authorDingil, Hasan Basri
dc.contributor.authorCorum, Orhan
dc.date.accessioned2024-12-24T19:33:31Z
dc.date.available2024-12-24T19:33:31Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractCarprofen can be used in the castration process of male goats due to its low side effects, long elimination half-life, and long-term effect. However, no studies were found on the pharmacokinetics and physiological efficacy of carprofen when employed for castration in male goats. The aim of this study was to determine the effect of xylazine (0.05 mg/kg, intramuscular) on the pharmacokinetics and physiological efficacy following intravenous administration of carprofen (4 mg/kg, intravenous) in male goat kids castrated using the burdizzo method. Thirty male Kilis goat kids (5-6 months and 18-30 kg of body weight) were randomly assigned to five groups (n = 6) as follows: healthy control (HC), castration control (CAST), castration+carprofen (CAST+CRP), castration+xylazine (CAST+XYL), and castration+xylazine+carprofen (CAST+XYL+CRP). Plasma concentrations of carprofen were analyzed via a non-compartmental method. Physiological parameters including serum cortisol, scrotal temperature, rectal temperature, and scrotal circumference were determined. Xylazine caused a decrease in the volume of distribution and clearance and an increase in the area under the curve of carprofen in CAST+XYL+CRP group (p < 0.05). The mean cortisol concentrations in CAST+CRP and CAST+XYL remained lower compared to CAST (p < 0.05). The mean cortisol concentrations in CAST+XYL+CRP were lower than in CAST+CRP and CAST+XYL (p < 0.05). In addition, the effect of carprofen administration alone on reducing the initial cortisol response to castration was observed from 6 to 48 h, while in combination with xylazine, it was observed immediately up to 48 h. No treatment differences were observed in rectal temperature, scrotal temperature, and scrotal circumference (p > 0.05). Xylazine caused an increase in plasma concentration and a decrease in clearance of carprofen after co-administration. However, when the effect of the combined administration of carprofen with xylazine on cortisol is evaluated, their combined use in castration process may be beneficial.
dc.identifier.doi10.3390/ani13172700
dc.identifier.issn2076-2615
dc.identifier.issue17
dc.identifier.pmid37684964
dc.identifier.scopus2-s2.0-85170219453
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ani13172700
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8175
dc.identifier.volume13
dc.identifier.wosWOS:001065317700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofAnimals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectcastration
dc.subjectcarprofen
dc.subjectcortisol
dc.subjectpharmacokinetics
dc.subjectxylazine
dc.titleEffect of Xylazine on Pharmacokinetics and Physiological Efficacy of Intravenous Carprofen in Castrated Goats Kids
dc.typeArticle

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