Investigation of the histopathological level of Ki-67, caspase-3 expressions of the effects of hesperidin on wound healing in the rat esophagus

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dc.authoriddurgun, cemalettin/0000-0002-5797-7926
dc.contributor.authorDurgun, Cemalettin
dc.contributor.authorKirman, Gulsen
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-12-24T19:30:19Z
dc.date.available2024-12-24T19:30:19Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractPurpose: The effects of hesperidin application on the wound caused by esophageal burns were investigated in this study. Methods: Wistar albino rats were divided into three groups: Control group: only 1 mL of 0.09% NaCl was administered i.p. for 28 days; Burn group: An alkaline esophageal burn model was created with 0.2 mL of 25% NaOH orally by gavage-1 mL of 0.09% NaCl was administered i.p. for 28 days; Burn+Hesperidin group: 1 mL of 50 mL/kg of hesperidin was given i.p. for 28 days to rats after burn injury. Blood samples were collected for biochemical analysis. Esophagus samples were processed for histochemical staining and immunohistochemistry. Results: Malondialdehyde (MDA) and myeloperoxidase (MPO) levels were significantly increased in Burn group. Glutathione (GSH) content and histological scores of epithelialization, collagen formation, neovascularization was decreased. After hesperidin treatment, these values were significantly improved in the Burn+Hesperidin group. In the Burn group, epithelial cells and muscular layers were degenerated. Hesperidin treatment restored these pathologies in Burn+Hesperidin group. Ki-67 and caspase-3 expressions were mainly negative in control group; however, the expression was increased in the Burn group. In the Burn+Hesperidin group, Ki-67 and caspase-3 immune activities were reduced. Conclusion: Hesperidin dosage and application methods can be developed as an alternative treatment for burn healing and treatment.
dc.identifier.doi10.1590/acb381723
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.pmid37098927
dc.identifier.scopus2-s2.0-85153987254
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/acb381723
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7489
dc.identifier.volume38
dc.identifier.wosWOS:000992135500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectEsophagus
dc.subjectBurns
dc.subjectApoptosis
dc.subjectKi-67 antigen
dc.subjectRats
dc.titleInvestigation of the histopathological level of Ki-67, caspase-3 expressions of the effects of hesperidin on wound healing in the rat esophagus
dc.typeArticle

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