Behavior, antioxidant, and metabolomics effects of Allium tuncelianum

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dc.authoridNemutlu, Emirhan/0000-0002-7337-6215
dc.authoridBAKIR, ahmet/0000-0003-0797-285X
dc.authoridEkin, Suat/0000-0002-6502-5028
dc.contributor.authorAbbak, Nigar
dc.contributor.authorNemutlu, Emirhan
dc.contributor.authorRecber, Tuba
dc.contributor.authorGul, Asli San Dagli
dc.contributor.authorAkkoyun, H. Turan
dc.contributor.authorAkkoyun, Mahire Bayramoglu
dc.contributor.authorYilmaz, Gulderen
dc.date.accessioned2024-12-24T19:24:09Z
dc.date.available2024-12-24T19:24:09Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractAllium species are consumed extensively as folkloric medicine and dietary elements, but limited studies have been conducted on them. In this study, the effects of an ethanol-water extract obtained from the underground bulb of Allium tuncelianum (Kollmann) ozhatay, B. Mathew & Siraneci (AT) on the behavioral, antioxidant, and metabolite parameters in rats were evaluated. AT was administered orally once a day at doses of 100 and 400 mg/kg to male Wistar albino rats for 10 consecutive days. The elevated plus maze, rotarod, and hotplate tests were used to examine anxiety-like behaviors, locomotor activities, and pain perception in the rats, respectively. Additionally, untargeted metabolomic analyses were performed on plasma samples and AT extracts using two orthogonal analytical platforms. The phenolic components, mainly fumaric acid, malic acid, vanillic acid, quercetin-3-arabinoside, hydrocinnamic acid, and gallocatechin, were determined in the extract. In addition, arbutin, salicylic acid, trehalose, and nicotinic acid were analyzed in the extract for the first time. The AT extract did not decrease the catalase, glutathione peroxidase, or superoxide dismutase levels; however, diazepam decreased some of those parameters significantly in the brain, liver, and kidney. Although both the AT and diazepam treatments resulted in an increase in anxiolytic-like effects compared to the control group, no significant differences were observed (p > .05). In the metabolomic analysis, significant changes were observed in the rats treated with AT and diazepam, and they caused significant changes in some metabolic pathways, including amino acid and fatty acid metabolism, compared to the control.
dc.identifier.doi10.1002/fsn3.4022
dc.identifier.endpage3551
dc.identifier.issn2048-7177
dc.identifier.issue5
dc.identifier.pmid38726412
dc.identifier.scopus2-s2.0-85186435837
dc.identifier.scopusqualityQ1
dc.identifier.startpage3538
dc.identifier.urihttps://doi.org/10.1002/fsn3.4022
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5871
dc.identifier.volume12
dc.identifier.wosWOS:001174214700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofFood Science & Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectAllium
dc.subjectAllium tuncelianum
dc.subjectantioxidant
dc.subjectanxiety
dc.subjectbehavior
dc.subjectelevated plus maze
dc.subjecthotplate
dc.subjectmetabolomics
dc.subjectrotarod
dc.subjecttunceli mountain garlic
dc.titleBehavior, antioxidant, and metabolomics effects of Allium tuncelianum
dc.typeArticle

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