The Effects of Sodium Tetraborate against Lead Toxicity in Rats: The Behavior of Some Metabolic Enzymes

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dc.authoridKARAGOZOGLU, FATMA/0000-0001-7970-0306
dc.contributor.authorAkkoyun, Mahire Bayramog
dc.contributor.authorTemel, Yusuf
dc.contributor.authorAkkoyun, H. Turan
dc.contributor.authorMelek, Sule
dc.contributor.authorKaragozoglu, Fatma
dc.contributor.authorBengu, A. Sukru
dc.contributor.authorGecmez, Kubra
dc.date.accessioned2024-12-24T19:27:50Z
dc.date.available2024-12-24T19:27:50Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study was planned to research the in vivo effects of lead (Pb) ions and sodium tetraborate (Na2B4O7) on G6PD and 6PGD, which are some of the enzymes of the pentose phosphate pathway, which carries vital importance for metabolism, and GR and GST, which are glutathione metabolism enzymes, and the in vitro effects of the same agents on the 6PGD enzyme. According to the in vivo analysis results, in comparison to the control group, the rat liver G6PD (p < 0.05), and 6PGD (p < 0.01) enzyme activities in the Na2B4O7 group were significantly lower. In addition, GR and GST enzyme activities were insignificantly lower in the Na2B4O7 group compared to the control group (p > 0.05). The Pb group had lower G6PD and 6PGD enzyme activity levels and higher GR and GST enzyme activity levels compared to the control group, while these changes did not reach statistical significance (p > 0.05). In the in vitro analyses of the effects of Pb ions on the 6PGD enzyme that was purified out of rat liver with the 2 ',5 '-ADP-Sepharose 4B affinity chromatography method, it was determined that Pb ions (200-1200 mu M) increased the rat liver 6PGD enzyme activity levels by 33%. On the other hand Na2B4O7 was not significantly effective on 6PGD activity. These results will also contribute to future studies in understanding the physiopathology of the states triggered by Pb ions and sodium tetraborate (Na2B4O7).
dc.identifier.doi10.1021/acsomega.3c01021
dc.identifier.endpage14798
dc.identifier.issn2470-1343
dc.identifier.issue16
dc.identifier.pmid37125134
dc.identifier.scopus2-s2.0-85153615282
dc.identifier.scopusqualityQ1
dc.identifier.startpage14792
dc.identifier.urihttps://doi.org/10.1021/acsomega.3c01021
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6818
dc.identifier.volume8
dc.identifier.wosWOS:000970113800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Omega
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.titleThe Effects of Sodium Tetraborate against Lead Toxicity in Rats: The Behavior of Some Metabolic Enzymes
dc.typeArticle

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