Protective Effect of Nerium oleander Distillate and Tarantula cubensis Alcoholic Extract on Cancer Biomarkers in Colon and Liver Tissues of Rats with Experimental Colon Cancer

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dc.contributor.authorDik, Burak
dc.contributor.authorCoskun, Devran
dc.contributor.authorEr, Ayse
dc.date.accessioned2024-12-24T19:30:37Z
dc.date.available2024-12-24T19:30:37Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground: Colon cancers are among the top three causes of cancer-related deaths. This study is a continuation of previous research aiming to identify effective treatments. Objective: This study investigated the effects of Tarantula cubensis alcoholic extract (TCAE) and Nerium oleander (NO) distillate on the levels of midkine, transforming growth factor (TGF)-beta, vascular endothelial growth factor (VEGF), alpha-fetoprotein (AFP), cyclooxygenase (COX)-2, insulin-like growth factor (IGF) and caspase-3 in the liver and colon tissues of rats with experimentally induced colon cancer. Methods: The liver and colon tissues of rats were homogeneously divided into control, colon cancer (azoxymethane, AZM), AZM + TCAE, and AZM + NO distillate groups. The levels of midkine, TGF-beta, VEGF, AFP, COX-2, IGF, and caspase-3 in the colon and liver tissues were measured by ELISA. Results: The levels of all parameters in colon and liver tissues in the AZM group were higher (p<0.05) than those in the control group. TCAE and NO distillate prevented (p < 0.05) increases in midkine, TGF-beta, VEGF, AFP, COX-2, IGF, and caspase-3 levels in the colon. NO distillate prevented the increase in all parameters except IGF, whereas TCAE prevented the increase in all values apart from COX-2 and IGF levels in the liver (p<0.05). Conclusion: NO distillate and TCAE may prevent the studied markers from reaching specified levels observed in the colon in AZM-induced colon cancer. The increases in the levels of the parameters in the liver were not as severe as those in the colon; however, an 18-week study period may not be sufficient for liver metastasis formation. Future molecular studies should investigate the mechanisms and pathways of these treatments in greater detail.
dc.description.sponsorshipScientific Research Project of Selcuk University, Turkey [18401174]
dc.description.sponsorshipThis study was supported by The Scientific Research Project of Selcuk University, Turkey (Project Number: 18401174).
dc.identifier.doi10.2174/1871520621666210903120253
dc.identifier.endpage1969
dc.identifier.issn1871-5206
dc.identifier.issn1875-5992
dc.identifier.issue10
dc.identifier.pmid34477527
dc.identifier.scopus2-s2.0-85130616402
dc.identifier.scopusqualityQ2
dc.identifier.startpage1962
dc.identifier.urihttps://doi.org/10.2174/1871520621666210903120253
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7608
dc.identifier.volume22
dc.identifier.wosWOS:000840124400011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofAnti-Cancer Agents in Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectTarantula cubensis alcoholic extract
dc.subjectNerium oleander distillate
dc.subjectcolon cancer
dc.subjectmidkine
dc.subjectvascular endothelial growth factor
dc.subjectalpha-fetoprotein
dc.titleProtective Effect of Nerium oleander Distillate and Tarantula cubensis Alcoholic Extract on Cancer Biomarkers in Colon and Liver Tissues of Rats with Experimental Colon Cancer
dc.typeArticle

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