Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep

Basit Öğe Kaydı
dc.authoridCoskun, Alparslan/0000-0002-2242-9647
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridYilmaz, Gokhan/0000-0001-6495-5488
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.contributor.authorGungor, Huseyin
dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorKumru, Alper Serhat
dc.contributor.authorYilmaz, Gokhan
dc.contributor.authorCoskun, Devran
dc.contributor.authorCoskun, Alparslan
dc.date.accessioned2024-12-24T19:29:35Z
dc.date.available2024-12-24T19:29:35Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractThe aim of this study is to determine the pharmacokinetic change after intravenous administration of meloxicam at doses of 0.5, 1 and 2 mg/kg to sheep. The study was carried out on six Akkaraman sheep. Meloxicam was administered intravenously to each sheep at 0.5, 1, and 2 mg/kg doses in a longitudinal pharmacokinetic design with a 15-day washout period. Plasma concentrations of meloxicam were determined using the high performance liquid chromatography-ultraviolet, and pharmacokinetic parameters were evaluated by non-compartmental analysis. Meloxicam was detected up to 48 h in the 0.5 mg/kg dose and up to 96 h in the 1 and 2 mg/kg doses. As the dose increased from 0.5 to 2 mg/kg, terminal elimination half-life, and dose normalized area under the concentration versus time curve increased and total clearance decreased. Compared to the 1 mg/kg dose, it was determined that V(dss )decreased and C-0.083h increased in the 2 mg/kg dose. Meloxicam provided the therapeutic concentration of >0.39 mu g/mL reported in other species for 12, 48 and 96 h at 0.5, 1 and 2 mg/kg doses, respectively. These results show that meloxicam exhibits non-linear pharmacokinetics and will achieve unpredictable plasma concentrations when administered IV for a rapid effect at dose of >= 1 mg/kg in sheep.
dc.identifier.doi10.1111/jvp.13422
dc.identifier.endpage207
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue3
dc.identifier.pmid38033195
dc.identifier.scopus2-s2.0-85178223399
dc.identifier.scopusqualityQ1
dc.identifier.startpage202
dc.identifier.urihttps://doi.org/10.1111/jvp.13422
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7152
dc.identifier.volume47
dc.identifier.wosWOS:001111260300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectincreasing dose
dc.subjectmeloxicam
dc.subjectpharmacokinetics
dc.subjectsheep
dc.titlePharmacokinetics of meloxicam following intravenous administration at different doses in sheep
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu