Factors affecting anxiety, depression, and stress among patients with hepatocellular carcinoma during COVID-19 pandemic

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridBAGCI, NAZLICAN/0000-0001-8914-5465
dc.authoridTamer, Murat/0000-0001-9142-1844
dc.contributor.authorAkbulut, S.
dc.contributor.authorTamer, M.
dc.contributor.authorKucukakcali, Z.
dc.contributor.authorAkyuz, M.
dc.contributor.authorSaritas, H.
dc.contributor.authorBagci, N.
dc.contributor.authorCiftci, F.
dc.date.accessioned2024-12-24T19:33:22Z
dc.date.available2024-12-24T19:33:22Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstract- OBJECTIVE: Patients with chron-ic disease whose treatments are limited may ex-perience depression, anxiety, and stress-related symptoms, as well as an increase in the levels of these conditions. This study aims to determine the factors affecting the depression, stress, and anxiety levels of hepatocellular carcinoma (HCC) patients due to the fear of COVID-19 exposure.PATIENTS AND METHODS: 118 patients with ad-vanced HCC treated with non-transplant treatment options or on the waiting list due to the lack of a do-nor were enrolled. To evaluate the stress, depres-sion, and anxiety levels during the COVID-19 pro-cess, Depression Anxiety Stress Scales (DASS-21) and the Coronavirus Anxiety Scale (CAS) were ad-ministered to 118 patients through a face-to-face interview. Sociodemographic and clinical charac-teristics were recorded, and the primary endpoint measure was the total score of DASS. In addition, the multilayer perceptron (MLP) model was con-structed to predict the scores of the DASS-21 total.RESULTS: There were significant differences be-tween DASS depression (p=0.010; p=0.030) DASS anxiety (p=0.010; p=0.010) and DASS total (p=0.046; p=0.023) scores in terms of gender and protective effect of the vaccine. Also, a significant difference between gender for the CAS scale was determined (p=0.044). The median score of the DASS total in the COVID-19 group was higher than in the non-COVID-19 group; however, the increase was not sig-nificant. MLP model revealed that chronic disease, gender, age, place of residence, smoking, type of vaccine, and COVID-19 exposure were the most im-portant predictors for the DASS total. CONCLUSIONS: Chronic disease, gender, and age were prominent factors in predicting the DASS-21 total score in HCC patients. There-fore, the crucial factors were clinically consid-ered for managing depression, stress, and anxi-ety in HCC patients.
dc.identifier.endpage712
dc.identifier.issn1128-3602
dc.identifier.issue2
dc.identifier.pmid36734727
dc.identifier.scopus2-s2.0-85147206656
dc.identifier.scopusqualityQ2
dc.identifier.startpage704
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8112
dc.identifier.volume27
dc.identifier.wosWOS:000933582100018
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectHepatocellular carcinoma
dc.subjectCOVID-19 pandemic
dc.subjectDepression
dc.subjectAnxiety
dc.subjectStress
dc.titleFactors affecting anxiety, depression, and stress among patients with hepatocellular carcinoma during COVID-19 pandemic
dc.typeArticle

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