Safety analysis of different ıntensities of elf-pemf in terms of apoptotic, inflammatory, and transcription factor NF-?b expression levels in rat liver

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dc.contributor.authorGokce, Yasin
dc.contributor.authorSeker, Ugur
dc.contributor.authorOzoner, Merve Pekince
dc.date.accessioned2024-12-24T19:30:03Z
dc.date.available2024-12-24T19:30:03Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground and Aim: The purpose of this research was to ascertain how exposure to extremely low-frequency pulsed electromagnetic fields (ELFPEMFs) at varying intensities affects apoptosis-related protein expression levels and liver morphology in rats. Materials and Methods: In this experimental study, 40 Wistar albino rats were randomly divided into 4 groups, with 10 animals in each group: Control, Sham, 1 milli Tesla (1mT), and 5 mT groups. The control group did not expose any application during the experiment. Animals in the sham group were placed into the closed ELF-PEMF exposure environment, but the device was kept closed. The rats in the 1mT and 5mT groups were placed into a closed ELF-PEMF exposure environment, and the magnetic field application was applied 5 days a week for 4 hours a day for 8 weeks. At the end of the study, the animals were sacrificed, and their liver tissues were examined morphologically, and the expression levels of proteins related to apoptosis and inflammation in these tissues were analyzed. Results: Our results indicated that ELF-PEMFs did not lead to any exact morphological alterations in the groups. Tissue apoptotic Bax and Caspase the control group. Additionally, pro-inflammatory TNF-alpha and transcription factor NF-kappa B in the 1mT and 5mT groups were similar (p>0.05) to each other and the control group. ELF-PEMF in rats.
dc.description.sponsorshipHarran University Scientific Research Projects [22128]
dc.description.sponsorshipFinancial Disclosure: This study was supported by Harran University Scientific Research Projects (project number: 22128) .
dc.identifier.doi10.14744/hf.2024.2024.0005
dc.identifier.endpage183
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue4
dc.identifier.pmid39524317
dc.identifier.scopus2-s2.0-85205214047
dc.identifier.scopusqualityQ3
dc.identifier.startpage178
dc.identifier.urihttps://doi.org/10.14744/hf.2024.2024.0005
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7360
dc.identifier.volume5
dc.identifier.wosWOS:001318736200003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofHepatology Forum
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectApoptosis
dc.subjectELF-PEMF
dc.subjectinflammation
dc.subjectliver
dc.subjectNF-kappa B.
dc.titleSafety analysis of different ıntensities of elf-pemf in terms of apoptotic, inflammatory, and transcription factor NF-?b expression levels in rat liver
dc.typeArticle

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