Impact of oxidative stress on myocardial performance in patients with diabetes: a focus on subclinical left ventricular dysfunction

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dc.authoridOksen, Dogac/0000-0003-4548-9543
dc.contributor.authorOksen, Dogac
dc.contributor.authorAslan, Muzaffer
dc.date.accessioned2024-12-24T19:29:38Z
dc.date.available2024-12-24T19:29:38Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractIntroduction Oxidative stress is known to affect left ventricular functions negatively. There is a strong bidirectional connection between diabetes mellitus (DM) and oxidative stress. In parallel, left ventricular dysfunction is observed more frequently, even in patients with DM without other risk factors. In this context, the objective of this study is to comparatively investigate the potential relationship between oxidative stress and subclinical left ventricular dysfunction (SCLVD) assessed by Myocardial Performance Index (MPI) in patients with and without DM. Research design and methods The sample of this observational cross-sectional single-center study consisted of 151 patients who were evaluated for oxidative stress and SCLVD by tissue Doppler echocardiography. Patients' total oxidant status (TOS), total antioxidant status (TAS), and Oxidative Stress Index (OSI) values were calculated. The effects of oxidative stress and DM on MPI were analyzed. Results There were 81 patients with DM (mean age: 46.17 +/- 10.33 years) and 70 healthy individuals (mean age: 45.72 +/- 9.04 years). Mean TOS and OSI values of the DM group were higher than healthy individuals (5.72 +/- 0.55 vs 5.31 +/- 0.50, p = <0.001; and 4.92 +/- 1.93 vs 1.79 +/- 0.39, p = <0.001; respectively). The mean TAS value of the DM group was significantly lower than the healthy group (1.21 +/- 0.40 vs 3.23 +/- 0.51, p = <0.001). There was a significant correlation between OSI and MPI mitral in the DM group (R 0.554, p = <0.001) but not in the healthy group (R -0.069, p=0.249). Conclusions Both oxidative stress and myocardial dysfunction were found to be more common in patients with DM. The study's findings indicated the negative effect of oxidative stress on myocardial functions. Accordingly, increased oxidative stress caused more significant deterioration in MPI in patients with DM compared with healthy individuals.
dc.identifier.doi10.1136/bmjdrc-2024-004153
dc.identifier.issn2052-4897
dc.identifier.issue3
dc.identifier.pmid38886070
dc.identifier.scopus2-s2.0-85196587003
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1136/bmjdrc-2024-004153
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7186
dc.identifier.volume12
dc.identifier.wosWOS:001251129700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmj Publishing Group
dc.relation.ispartofBmj Open Diabetes Research & Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectDiabetes Mellitus, Type 2
dc.subjectOxidative Stress
dc.subjectMyocardium
dc.titleImpact of oxidative stress on myocardial performance in patients with diabetes: a focus on subclinical left ventricular dysfunction
dc.typeArticle

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