The Negative Effects of Subclinical Pregnancy Toxaemia on Fetal Skeletal Muscle Development and Evaluation of the Protective Effects of Dietary l‐Carnitine Supplementation in Sheep

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dc.contributor.authorAli Osman Turgut
dc.contributor.authorBanu Kandil
dc.contributor.authorEbru Karakaya Bilen
dc.contributor.authorDavut Koca
dc.contributor.authorAli Ünver
dc.contributor.authorFatma İşbilir
dc.contributor.authorÖzgür Özöner
dc.contributor.authorRahmi Doğan
dc.contributor.authorMuhammed Furkan Önen
dc.contributor.authorMehmet Eroğlu
dc.contributor.authorSait Şendağ
dc.contributor.authorAxel Wehrend
dc.date.accessioned2025-06-10T12:09:53Z
dc.date.available2025-06-10T12:09:53Z
dc.date.issued2025-06
dc.departmentFakülteler, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü
dc.description.abstractThis study evaluated the effects of subclinical pregnancy toxaemia (SPT) on fetal skeletal muscle development and assessed the potential protective role of L-carnitine supplementation during gestation. A total of 18 crossbred Hamdani ewes underwent oestrous synchronisation, natural mating and pregnancy confirmation via ultrasonography on day 45 post-mating. The ewes were managed according to NRC (2007) dietary guidelines until day 100 of gestation, after which they were assigned to three experimental groups: subclinical PT group (group 1; G1, n = 6), treatment group (subclinical PT + L-carnitine, group 2; G2, n = 6) and control group (group 3; G3, n = 6). Blood β-hydroxybutyrate (βHBA) concentrations were measured on day 100 and 138 of the gestation. Then, all ewes were slaughtered for fetal muscle sampling from the Musculus Longissimus Dorsi (MLD) and Vastus Lateralis (VL). Results indicated a significant reduction in muscle fibre number and fibre diameter in both MLD and VL in the SPT group (G1) compared to the control (G3) (p < 0.05). No significant differences were observed between G1 and G2 or between G2 and G3 for these parameters (p > 0.05). On the other hand, large effect sizes for group and pairwise comparisons imply that SPT may negatively affect prenatal muscle development and L-carnitine supports muscle development during the prepartum period. These findings highlight the negative effects of SPT and protective effects of L-carnitine supplementation on fetal skeletal muscle development in ewes with SPT. The observed deficits may negatively impact postnatal growth, survival rates and meat quality. Further investigations are warranted to optimise maternal nutrition strategies and evaluate therapeutic interventions aimed at mitigating the adverse impacts of SPT on fetal muscle development in ruminants. Furthermore, L-carnitine supplementation may be a useful in compensating for the negative effects of SPT.
dc.identifier.doi10.1111/rda.70088
dc.identifier.issn0936-6768
dc.identifier.issn1439-0531
dc.identifier.issue6
dc.identifier.pmid40485431
dc.identifier.urihttps://doi.org/10.1111/rda.70088
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8710
dc.identifier.volume60
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.institutionauthorTurgut, Ali Osman
dc.institutionauthoridhttps://orcid.org/0000-0001-6863-0939
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofReproduction in Domestic Animals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectL‐carnitine
dc.subjectmuscle development
dc.subjectreproduction
dc.subjectsheep
dc.subjectsubclinical pregnancy toxaemia.
dc.titleThe Negative Effects of Subclinical Pregnancy Toxaemia on Fetal Skeletal Muscle Development and Evaluation of the Protective Effects of Dietary l‐Carnitine Supplementation in Sheep
dc.typejournal-article
oaire.citation.issue6
oaire.citation.volume60

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