Protective Effects of Alpha-Lipoic Acid against 5-Fluorouracil-Induced Gastrointestinal Mucositis in Rats

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dc.authoridSayiner, Serkan/0000-0002-3297-5369
dc.authoridSEHIRLI, AHMET OZER/0000-0002-5175-9290
dc.authoridSah, Huseyin/0000-0003-0480-1609
dc.authoridCeylanli, Deniz/0000-0003-2352-052X
dc.authoridTerali, Kerem/0000-0002-9964-6383
dc.contributor.authorCeylanli, Deniz
dc.contributor.authorSehirli, Ahmet Ozer
dc.contributor.authorGencosman, Sevgi
dc.contributor.authorTerali, Kerem
dc.contributor.authorSah, Huseyin
dc.contributor.authorGulmez, Nurhayat
dc.contributor.authorSayiner, Serkan
dc.date.accessioned2024-12-24T19:33:31Z
dc.date.available2024-12-24T19:33:31Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractAlpha-lipoic acid (ALA) is extensively utilized in multivitamin formulas and anti-aging products. The purpose of this study was to investigate the potential protective benefits of ALA on 5-fluorouracil (5-FU)-induced gastrointestinal mucositis in Wistar albino rats. Tissues from the stomach, small intestine, and large intestine were excised, and blood sera were obtained to identify biochemical indices such as TNF-alpha, IL-1 beta, MDA, GPx, SOD, MMP-1, -2, -8, and TIMP-1. A histopathological study was also performed. The results revealed mucositis-elevated TNF-, IL-1, MDA, MMP-1, -2, -8, and TIMP-1 levels in both tissues and sera, and these values dropped dramatically following ALA treatment. Reduced SOD and GPx activities in mucositis groups were reversed in ALA-treated groups. The damage produced by mucositis in the stomach and small intestine regressed in the ALA-treated group, according to histopathological evaluation. Consequently, the implementation of ALA supplementation in 5-FU therapy may act as a protective intervention for cancer patients with gastrointestinal mucositis. In light of the findings, ALA, a food-derived antioxidant with pleiotropic properties, may be an effective treatment for 5-FU-induced gastrointestinal mucositus, and prevent oxidative stress, inflammation, and tissue damage in cancer patients receiving 5-FU therapy.
dc.identifier.doi10.3390/antiox11101930
dc.identifier.issn2076-3921
dc.identifier.issue10
dc.identifier.pmid36290656
dc.identifier.scopus2-s2.0-85140481155
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/antiox11101930
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8179
dc.identifier.volume11
dc.identifier.wosWOS:000872106800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofAntioxidants
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subject5-fluorouracil
dc.subjectalpha-lipoic acid
dc.subjectoxidative stress
dc.subjectgastrointestinal mucositis
dc.subjectinflammation
dc.titleProtective Effects of Alpha-Lipoic Acid against 5-Fluorouracil-Induced Gastrointestinal Mucositis in Rats
dc.typeArticle

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