In Vitro Antitumor and Antioxidant Capacity as well as Ameliorative Effects of Fermented Kefir on Cyclophosphamide-Induced Toxicity on Cardiac and Hepatic Tissues in Rats

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dc.authoridCETIK YILDIZ, Songul/0000-0002-7855-5343
dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.authoridIRMAK, Halit/0000-0002-8184-9377
dc.contributor.authorYildiz, Songul Cetik
dc.contributor.authorDemir, Cemil
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorIrmak, Halit
dc.contributor.authorCengiz, Betul Peker
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:33:33Z
dc.date.available2024-12-24T19:33:33Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractFermented prebiotic and probiotic products with kefir are very important to slow down and prevent the growth of tumors and to treat cancer by stimulating the immune response against tumor cells. Cyclophosphamide (CPx) is widely preferred in cancer treatment but its effectiveness in high doses is restricted because of its side effects. The aim of this study was to investigate the protective effects of kefir against CPx-induced heart and liver toxicity. In an experiment, 42 Wistar albino rats were divided into six treatment groups: the control (Group 1), the group receiving 150 mg/kg CPx (Group 2), the groups receiving 5 and 10 mg/kg kefir (Groups 3 and 4) and the groups receiving 5 and 10 mg/kg kefir + CPx (Group 5 and 6). Fermented kefirs obtained on different days by traditional methods were mixed and given by gavage for 12 days, while a single dose of CPx was administered intraperitoneally (i.p.) on the 12th day of the experiment. It was observed that alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatinine kinase-MB (CK-MB), ischemia modified albumin (IMA) and Troponin I values, which indicate oxidative stress, increased in the CPx-administered group, and this level approached that of the control in the CPx + kefir groups. Likewise, as a result of the kefir, the rats' CPx-induced histopathological symptoms were reduced, and their heart and liver tissue were significantly improved. In conclusion, it was observed that kefir had a cytoprotective effect against CPx-induced oxidative stress, hepatotoxicity and cardiotoxicity, bringing their biochemical parameters closer to those of the control by suppressing oxidative stress and reducing tissue damage.
dc.identifier.doi10.3390/biomedicines12061199
dc.identifier.issn2227-9059
dc.identifier.issue6
dc.identifier.pmid38927407
dc.identifier.scopus2-s2.0-85197265132
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/biomedicines12061199
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8195
dc.identifier.volume12
dc.identifier.wosWOS:001254517400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofBiomedicines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectkefir
dc.subjectcyclophosphamide
dc.subjectoxidative stress
dc.subjectantioxidant
dc.subjectantitumor
dc.subjectrats
dc.titleIn Vitro Antitumor and Antioxidant Capacity as well as Ameliorative Effects of Fermented Kefir on Cyclophosphamide-Induced Toxicity on Cardiac and Hepatic Tissues in Rats
dc.typeArticle

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