The protection afforded by kefir against cyclophosphamide induced testicular toxicity in rats by oxidant antioxidant and histopathological evaluations

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dc.authoridPEKER CENGIZ, BETUL/0000-0002-2503-7446
dc.authoridCETIK YILDIZ, Songul/0000-0002-7855-5343
dc.authoridIRMAK, Halit/0000-0002-8184-9377
dc.authoridDEMIR, CEMIL/0000-0002-6365-0196
dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.contributor.authorYildiz, Songul Cetik
dc.contributor.authorDemir, Cemil
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorIrmak, Halit
dc.contributor.authorCengiz, Betul Peker
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:27:59Z
dc.date.available2024-12-24T19:27:59Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractCyclophosphamide (CTX) is the most commonly used effective alkylating drug in cancer treatment, but its use is restricted because its toxic side effect causes testicular toxicity. CTX disrupts the tissue redox and antioxidant balance and the resulting tissue damage causes oxidative stress. In our study based on this problem, kefir against CTX-induced oxidative stress and testicular toxicity were investigated. Rats were divided into 6 groups: control, 150 mg/kg CTX, 5 and 10 mg/kg kefir, 5 and 10 mg/kg kefir + 150 CTX. While the fermented kefirs were mixed and given to the rats for 12 days, CTX was given as a single dose on the 12th day of the experiment. Testis was scored according to spermatid density, giant cell formation, cells shed into tubules, maturation disorder, and atrophy. According to our biochemical findings, the high levels of total oxidant status (TOS), and the low levels of total antioxidant status (TAS) in the CTX group, which are oxidative stress markers, indicate the toxic effect of CTX, while the decrease in TOS levels and the increase in TAS levels in the kefir groups indicate the protective effect of kefir. In the CTX-administered group, tubules with impaired maturation and no spermatids were observed in the transverse section of the testicle, while in the kefir groups, the presence of near-normal tubule structures and tubule lumens despite CTX showed the protective effect of kefir. In our study, it was observed that kefir had a protective and curative effect on CTX-induced toxicity and oxidative stress and could be a strong protector.
dc.description.sponsorshipMardin Artuklu University BAP Coordination Office [MAU.BAP.20, SHMYO.004, 784-145 / 2020]
dc.description.sponsorshipThis study was financed by Mardin Artuklu University BAP Coordination Office (MAU.BAP.20.SHMYO.004). Ethical statement: This exprimental study was approved by Ethics Committee of Eskisehir Osmangazi University Animal Experiments Local Ethics Committee (784-145 / 2020. And the entire study was conducted in accordance with the Animal Experiments Local Ethics Committee Directive. A part of this study was presented at IV. International Siirt Conference on Scientific Research Siirt University, November 17-18, 2023.
dc.identifier.doi10.1038/s41598-024-67982-y
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid39122852
dc.identifier.scopus2-s2.0-85200892919
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41598-024-67982-y
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6865
dc.identifier.volume14
dc.identifier.wosWOS:001288468500070
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectCyclophosphamide
dc.subjectTesticular toxicity
dc.subjectOxidative stress
dc.subjectKefir
dc.subjectAntioxidant
dc.subjectRats
dc.titleThe protection afforded by kefir against cyclophosphamide induced testicular toxicity in rats by oxidant antioxidant and histopathological evaluations
dc.typeArticle

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