Age-related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep

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dc.authoridCeyhan, Hatice Rumeysa/0000-0001-9239-5537
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.contributor.authorCoskun, Devran
dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorCetin, Gul
dc.contributor.authorIrmak, Mehmet
dc.contributor.authorCeyhan, Hatice Rumeysa
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-12-24T19:29:35Z
dc.date.available2024-12-24T19:29:35Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractThe pharmacokinetics of meloxicam was studied in 1-, 6-, and 12-month- old sheep following a single intravenous (i.v.) dose of 1 mg/kg. The experiments were carried out when the Romanov sheep were 1 month old (7.93 +/- 0.91 kg), 6 months old (27.47 +/- 4.91 kg), and 12 months old (37.10 +/- 3.64 kg). Meloxicam concentration in plasma was determined by high-performance liquid chromatography and the data collected were evaluated by non-compartmental kinetic analysis. Meloxicam was detected in the plasma up to 72 h following i.v. administration in all age groups. The volume of distribution at steady state (Vdss) and total body clearance (ClT) were significantly higher in 1- month- old (304.87 mL/kg and 16.57 mL/h/kg) than in 12- month- old (193.43 mL/kg and 10.50 mL/h/kg) sheep. The area under the concentration- time curve from 0 to 72 h value of meloxicam was lower in 1- month- old (58.51 h*mu g/mL) compared to 12- month- old (92.59 h*mu g/mL) sheep. There was no difference in t1/ 2.z value in different age groups. The body extraction ratio values for meloxicam ranged from 0.0186 to 0.0719 after i.v. administration in all age groups. Meloxicam showed an increase in plasma concentration and a decrease in Vdss and ClT in 12- month- old compared to 1- month- old sheep. Compared to 1- month- old and 12- month- old sheep, there was no difference in these parameters in 6- month- old sheep. Because the age of sheep has an influence on the pharmacokinetics of meloxicam, dosage apparently may need to be adjusted for age.
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Erzincan Binali Yildirim, Turkiye
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Erzincan Binali Yildirim, Turkiye
dc.identifier.doi10.1111/jvp.13404
dc.identifier.endpage331
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue5
dc.identifier.pmid37488663
dc.identifier.scopus2-s2.0-85165564472
dc.identifier.scopusqualityQ1
dc.identifier.startpage326
dc.identifier.urihttps://doi.org/10.1111/jvp.13404
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7151
dc.identifier.volume46
dc.identifier.wosWOS:001035604200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectage-related pharmacokinetics
dc.subjectHPLC
dc.subjectintravenous
dc.subjectmeloxicam
dc.subjectsheep
dc.titleAge-related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep
dc.typeArticle

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