Effect of Body Size on Plasma and Tissue Pharmacokinetics of Danofloxacin in Rainbow Trout (Oncorhynchus mykiss)

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dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.contributor.authorUney, Kamil
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorMarin, Pedro
dc.contributor.authorCoskun, Devran
dc.contributor.authorTerzi, Ertugrul
dc.contributor.authorBadillo, Elena
dc.contributor.authorCorum, Orhan
dc.date.accessioned2024-12-24T19:33:31Z
dc.date.available2024-12-24T19:33:31Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractDanofloxacin is a fluoroquinolone antibiotic approved for use in fish. It can be used for bacterial infections in fish of all body sizes. However, physiological differences in fish depending on size may change the pharmacokinetics of danofloxacin and therefore its therapeutic efficacy. In this study, the change in the pharmacokinetics of danofloxacin in rainbow trout of various body sizes was revealed for the first time. The objective of this investigation was to compare the plasma and tissue pharmacokinetics of danofloxacin in rainbow trout of different body sizes. The study was conducted at 14 +/- 0.5 degrees C in fish of small, medium, and large body size and danofloxacin was administered orally at a dose of 10 mg/kg. Concentrations of this antimicrobial in tissues and plasma were quantified by high performance liquid chromatography with ultraviolet detector. The plasma elimination half-life (t1/2 lambda z), volume of distribution (Vdarea/F), total clearance (CL/F), peak concentration (Cmax), and area under the plasma concentration-time curve (AUC0-last) were 27.42 h, 4.65 L/kg, 0.12 L/h/kg, 2.53 mu g/mL, and 82.46 h center dot mu g/mL, respectively. Plasma t1/2 lambda z, AUC0-last and Cmax increased concomitantly with trout growth, whereas CL/F and Vdarea/F decreased. Concentrations in liver, kidney, and muscle tissues were higher than in plasma. Cmax and AUC0-last were significantly higher in large sizes compared to small and medium sizes in all tissues. The scaling factor in small, medium, and large fish was 1.0 for bacteria with MIC thresholds of 0.57, 0.79, and 1.01 mu g/mL, respectively. These results show that therapeutic efficacy increases with body size. However, since increases in danofloxacin concentration in tissues of large fish may affect withdrawal time, attention should be paid to the risk of tissue residue.
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Selcuk, Turkiye [21401007]
dc.description.sponsorshipThe project was supported by The Coordination of Scientific Research Projects, University of Selcuk, Turkiye (Project No:21401007).
dc.identifier.doi10.3390/ani14223302
dc.identifier.issn2076-2615
dc.identifier.issue22
dc.identifier.pmid39595354
dc.identifier.scopus2-s2.0-85210246929
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ani14223302
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8178
dc.identifier.volume14
dc.identifier.wosWOS:001363574200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofAnimals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectantibiotics
dc.subjectaquaculture
dc.subjectbody size related pharmacokinetics
dc.subjectHPLC
dc.subjectfluoroquinolones
dc.titleEffect of Body Size on Plasma and Tissue Pharmacokinetics of Danofloxacin in Rainbow Trout (Oncorhynchus mykiss)
dc.typeArticle

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