Alternations in interleukin-1? and nuclear factor kappa beta activity (NF-kB) in rat liver due to the co-exposure of Cadmium and Arsenic: Protective role of curcumin

dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.authoridBAYRAKDAR, Alpaslan/0000-0001-7967-2245
dc.authoridGUR, Bahri/0000-0003-0579-6354
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorGur, Bahri
dc.contributor.authorSezer, Canan Vejselova
dc.contributor.authorCengiz, Betuel Peker
dc.contributor.authorGur, Fatma
dc.contributor.authorBayrakdar, Alpaslan
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:27:03Z
dc.date.available2024-12-24T19:27:03Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractCadmium chloride (Cd) and sodium arsenite (As) are two prominent examples of non-biodegradable substances that accumulate in ecosystems, pose a serious risk to human health and are not biodegradable. Although the toxicity caused by individual use of Cd and As is known, the toxicity of combined use (Cd+As) to mammals is poorly understood. The present study aims to investigate the hepatoprotective effect of curcumin (CUR), a naturally occurring bioactive component isolated from the root stem of Curcuma longa Linn., in preventing liver damage caused by a Cd+As mixture. A group of 30 Sprague-Dawley rats were subjected to intraperitoneal administration of Cd+As (0.44 mg/kg+5.55 mg/kg i.p.) and CUR (100 or 200 mg/kg) for a period of 14 days. The experimental results showed that the animals treated with Cd+As exhibited changes in liver biochemical parameters, inflammation and oxidative stress at the end of the experiment. Administration of CUR significantly reduced inflammation, oxidative stress and lipid peroxidation in the Cd+As plus CUR groups compared to the Cd+As group. Furthermore, histological examination of the liver tissue showed that administration of CUR had led to a significant reduction in the liver damage observed in the Cd+As group. The present study provides scientific evidence for the protective effects of CUR against lipid peroxidation, inflammation, oxidative stress and liver damage induced by Cd+As in the liver of rats. The results of our in vivo experiments were confirmed by those of our molecular modelling studies, which showed that CUR can enhance the diminished antioxidant capacity caused by Cd+As.
dc.description.sponsorship[FHD-2022-2251]
dc.description.sponsorshipThe others would like to thank Eskisehir Osmangazi University, Scientific Research Projects Unit (FHD-2022-2251) for their support of our study.
dc.identifier.doi10.1016/j.etap.2023.104218
dc.identifier.issn1382-6689
dc.identifier.issn1872-7077
dc.identifier.pmid37451528
dc.identifier.scopus2-s2.0-85166560090
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.etap.2023.104218
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6488
dc.identifier.volume102
dc.identifier.wosWOS:001051926700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectCadmium chloride
dc.subjectCurcumin
dc.subjectInflammation
dc.subjectin silico
dc.subjectLiver damage
dc.subjectSodium arsenite
dc.titleAlternations in interleukin-1? and nuclear factor kappa beta activity (NF-kB) in rat liver due to the co-exposure of Cadmium and Arsenic: Protective role of curcumin
dc.typeArticle

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