Eco-friendly biosynthesized silver, copper, and nickel nanoparticles mediated Rheum ribes: Assessment of their cytotoxicity and antimicrobial activity

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dc.authoridhttps://orcid.org/0000-0002-6925-8371
dc.contributor.authorBahri Gür
dc.contributor.authorMustafa Cengiz
dc.contributor.authorCanan Vejselova Sezer
dc.contributor.authorOrhan Baytar
dc.contributor.authorÖmer Şahin
dc.contributor.authorAdnan Ayhanci
dc.contributor.authorHatice Mehtap Kutlu
dc.date.accessioned2025-01-10T12:03:24Z
dc.date.available2025-01-10T12:03:24Z
dc.date.issued2025-02
dc.departmentFakülteler, Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümü
dc.departmentFakülteler, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractBackground: The green synthesis of metallic nanoparticles has recently become a research area of increasing interest due to their potential applications in nanomedicine. Aim of study: This study aimed to investigate, for the first time, the anticancer properties of silver nanoparticles (Ag-NPs), copper oxide nanoparticles (CuO-NPs), and nickel oxide nanoparticles (NiO-NPs) on A549 and Beas-2B cell lines, as well as their antibacterial efficacy against Escherichia coli and Staphylococcus aureus strains, synthesized through a green synthesis approach utilizing Rheum ribes plant extract. Methodology: The current study introduces a sustainable and environmentally friendly method for the biosynthesis of Ag-NPs, CuO-NPs, and NiO-NPs utilizing the aqueous extract of Rhubarb (Rheum ribes). The spectroscopic and morphological properties of the Ag-NPs, CuO-NPs, and NiO-NPs obtained from the Rheum ribes extract were confirmed using different analytical techniques. Results: The Ag-NPs, CuO-NPs, and NiO-NPs exhibited different morphology with a size of about 7.90, 12.0, and 12.63 nm, respectively, and were free of impurities and highly stable particles. In addition, the NPs were further investigated for their anticancer and antibacterial properties. The anticancer effects of the NPs were assessed using the MTT assay and confocal microscopy in non-small cell lung cancer (A549) and healthy lung (Beas-2B) cells. The study results demonstrated that Ag-NPs, CuO-NPs, and NiO-NPs had cytotoxic effects on A549 cells that were concentration-based, having IC50 values of 4.16, 21.28, and 37.68 μg/mL, in that order. Additionally, it was observed that the above-mentioned NPs exhibited strong activity against bacteria. Conclusions: The nanoparticles derived from Rheum ribes extract appear to hold great potential as a class of nano-biomaterials intended for usage in biological fields.
dc.identifier.citationGür, B., Cengiz, M., Sezer, C. V., Baytar, O., Şahin, Ö., Ayhanci, A., & Kutlu, H. M. (2024). Eco-friendly biosynthesized silver, copper, and nickel nanoparticles mediated Rheum ribes: Assessment of their cytotoxicity and antimicrobial activity. Inorganic Chemistry Communications, 113755.
dc.identifier.doi10.1016/j.inoche.2024.113755
dc.identifier.issn1387-7003
dc.identifier.scopus2-s2.0-85212580240
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://10.1016/j.inoche.2024.113755
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8422
dc.identifier.volume172
dc.identifier.wosqualityQ1
dc.institutionauthorCengiz, Mustafa
dc.institutionauthorBaytar, Orhan
dc.institutionauthoridhttps://orcid.org/0000-0002-6925-8371
dc.institutionauthoridhttps://orcid.org/0000-0002-2915-202X
dc.language.isoen
dc.publisherElsevier BV
dc.relation.ispartofInorganic Chemistry Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Başka Kurum Yazarı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnti-bacterial agent
dc.subjectGreen synthesis
dc.subjectLung cancer
dc.subjectMetal nanoparticles
dc.subjectPolydispersity index
dc.subjectTauc plot
dc.titleEco-friendly biosynthesized silver, copper, and nickel nanoparticles mediated Rheum ribes: Assessment of their cytotoxicity and antimicrobial activity
dc.typejournal-article
oaire.citation.volume172

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