Evaluation of the effects of amiodarone and amiodarone plus dobutamine on survival in tilmicosin-induced toxicity by electrocardiography and biochemical parameters in goats

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dc.contributor.authorCoskun, D.
dc.contributor.authorIder, M.
dc.contributor.authorNaseri, A.
dc.contributor.authorDik, B.
dc.contributor.authorBahcivan, E.
dc.contributor.authorTras, B.
dc.contributor.authorEr, A.
dc.date.accessioned2024-12-24T19:29:57Z
dc.date.available2024-12-24T19:29:57Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractTilmicosin shows different degrees of cardiotoxic effect in various animal species depending on the route of administration and dose. We aimed to determine the effects of amiodarone and amiodarone+dobutamine treatments on tilmicosincardiotoxicity and survival time. 18 healthy goats were divided into tilmicosin, tilmicosin+amiodarone and tilmicosin+amiodarone+dobutamine groups. After drug administrations, the survival times of the animals in all groups were recorded. In addition, blood was drawn from the animals just before they died. Haemogram, troponin I, CK-MB, and other biochemical parameters were measured in all blood samples. Prolonged survival was observed in the treatment groups compared to the tilmicosin group. In the treatment groups, decreases in haemogram parameters, albumin, and total protein levels caused by tilmicosin could not be prevented, while the increase in troponin I level was prevented. In conclusion, while cardiotoxicity due to high troponin from tilmicosin was prevented, the survival rate was not affected in both treatment groups, and the survival time was extended at differing rates. In case of accidental or deliberate overdose of tilmicosin in animals, in addition to the use of amiodarone+dobutamine, the survival time may be prolonged, and the success may increase if the necessary symptomatic treatments and equipment support are available.
dc.description.sponsorshipSUPABK [20401008]
dc.description.sponsorshipWe thank Dr. EnverYazar for scientific con-tributions. This study is supported by SUPABK (20401008) .
dc.identifier.doi10.12681/jhvms.34146
dc.identifier.issn1792-2720
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85194910804
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.12681/jhvms.34146
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7323
dc.identifier.volume75
dc.identifier.wosWOS:001209307800005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherHellenic Veterinary Medical Soc
dc.relation.ispartofJournal of The Hellenic Veterinary Medical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectTilmicosin
dc.subjectAmiodarone
dc.subjectDobutamine
dc.subjectSurvival time
dc.subjectCardiotoxicity
dc.titleEvaluation of the effects of amiodarone and amiodarone plus dobutamine on survival in tilmicosin-induced toxicity by electrocardiography and biochemical parameters in goats
dc.typeArticle

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