Evaluation and 3D imaging of mineral structure changes of the rabbit (New Zealand) skull during developmental periods

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dc.authoridKARAN, MERYEM/0000-0002-1857-2256
dc.authoridYILMAZ, Yucehan/0000-0001-8422-0569
dc.authoridDAGOGLU HARK, Betul/0000-0002-5189-1929
dc.authoridGuzel, Baris Can/0000-0002-2504-120X
dc.authoridYILMAZ, SADIK/0000-0001-9511-5625
dc.authoridASLAN KANMAZ, YESIM/0000-0002-2401-1500
dc.contributor.authorKanmaz, Yesim Aslan
dc.contributor.authorBaygeldi, Saime Betuel
dc.contributor.authorGuezel, Baris Can
dc.contributor.authorYilmaz, Yuecehan
dc.contributor.authorKaran, Meryem
dc.contributor.authorHark, Betuel Dagoglu
dc.contributor.authorYilmaz, Sadik
dc.date.accessioned2024-12-24T19:28:34Z
dc.date.available2024-12-24T19:28:34Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study aimed to determine the morphometric measurements anatomically and CT images of skulls of healthy male and female rabbits during postnatal development, to analyse the data statistically and to demonstrate the structural changes in bone. A total of 40 rabbits (20 females and 20 males) were divided into four groups including prepubertal period (group I (0-1 month)), period between adolescence and adulthood (group II (3-5 month)) and later (young adult period as group III (1-3 years) and old adult period as group IV (3-5 years)), with five animals in each group. After the morphometric measurements, the surface area and volume values of the skull were calculated. The skulls were reconstructed using a 3D Slicer (5.0.2), which is used for 3D modelling. The cranial bones in each group were then crushed using a grinder so that the powdered samples were obtained for XRF (X-ray fluorescence technique). The p-value was statistically highly significant between group and gender (p < 0.001). In morphometric measurements, males were generally higher than females. Only PL, GBOC and GNB measurements were higher in females. The p-value between groups (in all measurements), between genders (in TL, GLN, FL, VL, OZB and GBN parameters) and between groups and genders (in TL, DL and VL parameters) was statistically highly significant (p < 0.001). The p-value between the groups, p-value between sexes and p-value between group and sex in Si, P, K, Ca, Ni, Zn, Sr, Sr and Ca/P elements were statistically significant (p < 0.001). Consequently, metric, volume and surface area measurements were taken through 3D modelling of skull bone in prepubertal period (group I), period between adolescence and adulthood (group II) and later (young adult period as group III and old adult period as group IV) of rabbits and the change in the mineral structure during postnatal development and effect of sex on this change were investigated. This might be the first study to assess both metric and mineral changes at four age intervals taken during the life span of rabbits.
dc.description.sponsorshipTUBITAK [221O052]
dc.description.sponsorshipThe skulls of the rabbits in this study belong to the animals used in the research project supported by TUBITAK (project no. 221O052).
dc.identifier.doi10.1111/ahe.13053
dc.identifier.issn0340-2096
dc.identifier.issn1439-0264
dc.identifier.issue3
dc.identifier.pmid38735036
dc.identifier.scopus2-s2.0-85192936633
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/ahe.13053
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7124
dc.identifier.volume53
dc.identifier.wosWOS:001219336700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAnatomia Histologia Embryologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subject3D imaging
dc.subjectmineral structure
dc.subjectmorphometry
dc.subjectrabbit
dc.subjectskull
dc.subjectXRF
dc.titleEvaluation and 3D imaging of mineral structure changes of the rabbit (New Zealand) skull during developmental periods
dc.typeArticle

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