Solvent Effect on Base-Free Synthesis 4-Substituted 2-Oxazolines via Intramolecular Cyclodemesylation

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dc.authoridGUNES, YAKUP/0000-0002-3967-8404
dc.contributor.authorDalkilic, Erdin
dc.contributor.authorGunes, Yakup
dc.date.accessioned2024-12-24T19:27:59Z
dc.date.available2024-12-24T19:27:59Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this present study, the solvent effect was examined for the synthesis of 2-oxazolines via intramolecular cyclodemesylation. To determine the solvent effect, aprotic/protic polar and nonpolar solvents were screened and polar protic solvents met the best result. The remarkable feature of this synthesis is that cyclization takes place in the absence of any base or reagent, in high yields (89-96%). As a result, a series of 4-substituted chiral 2-oxazolines were successfully synthesized through a four-step process, with overall yields reaching between 79% and 88% in a greener approach.
dc.identifier.doi10.1055/s-0042-1751491
dc.identifier.issn0936-5214
dc.identifier.issn1437-2096
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85173007923
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1055/s-0042-1751491
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6873
dc.identifier.volume35
dc.identifier.wosWOS:001069564500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofSynlett
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectsolvent effect
dc.subjectgreen chemistry
dc.subjectheterocycles
dc.subjectintramolecular cyclization
dc.subject2-oxazoline
dc.titleSolvent Effect on Base-Free Synthesis 4-Substituted 2-Oxazolines via Intramolecular Cyclodemesylation
dc.typeArticle

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