Solvent Effect on Base-Free Synthesis 4-Substituted 2-Oxazolines via Intramolecular Cyclodemesylation
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Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Georg Thieme Verlag Kg
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this present study, the solvent effect was examined for the synthesis of 2-oxazolines via intramolecular cyclodemesylation. To determine the solvent effect, aprotic/protic polar and nonpolar solvents were screened and polar protic solvents met the best result. The remarkable feature of this synthesis is that cyclization takes place in the absence of any base or reagent, in high yields (89-96%). As a result, a series of 4-substituted chiral 2-oxazolines were successfully synthesized through a four-step process, with overall yields reaching between 79% and 88% in a greener approach.
Açıklama
Anahtar Kelimeler
solvent effect, green chemistry, heterocycles, intramolecular cyclization, 2-oxazoline
Kaynak
Synlett
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
35
Sayı
7
