High carbohydrate diet decreases microbial diversity and increases IL-1? levels in mice colon

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dc.authoridaydin, Erkin/0000-0001-7811-2959
dc.contributor.authorUlutas, Mehmet Sefa
dc.contributor.authorAydin, Erkin
dc.contributor.authorCebeci, Aysun
dc.date.accessioned2024-12-24T19:24:28Z
dc.date.available2024-12-24T19:24:28Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractWestern diet is known to contribute to intestinal dysbiosis and the progression of inflammation. Although the Turkish diet has different macronutrient contents, the intestinal inflammatory disease incidences in T & uuml;rkiye are comparable to Western countries. Thus, we hypothesized that high carbohydrate diets also contribute to inflammation of the colon. We compared diets with different macronutrient compositions and investigated their effects on colonic microbiota, cytokine, histology, and tight junction protein levels. High carbohydrate diet caused the lowest microbial diversity and is accompanied by the highest expression of interleukin-1 beta and claudin-1. A low carbohydrate diet with zero fiber resulted in the lowest inflammatory markers as well as the lowest occludin and claudin levels. Overall, our results indicate that carbohydrate and fiber contents of the diets are important contributors to colon health.
dc.description.sponsorshipAbdullah Gul University
dc.description.sponsorshipThe authors would like to thank Ayca Lekesizcan for her help in histology, and Abdullah Gul University for the support.
dc.identifier.doi10.1007/s10068-024-01581-5
dc.identifier.endpage2211
dc.identifier.issn1226-7708
dc.identifier.issn2092-6456
dc.identifier.issue9
dc.identifier.pmid39130660
dc.identifier.scopus2-s2.0-85191980287
dc.identifier.scopusqualityQ2
dc.identifier.startpage2201
dc.identifier.urihttps://doi.org/10.1007/s10068-024-01581-5
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6003
dc.identifier.volume33
dc.identifier.wosWOS:001214172500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Society Food Science & Technology-Kosfost
dc.relation.ispartofFood Science and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectInflammation
dc.subjectMicrobiota
dc.subjectTight junction protein
dc.subjectCarbohydrate
dc.subjectDietary fiber
dc.titleHigh carbohydrate diet decreases microbial diversity and increases IL-1? levels in mice colon
dc.typeArticle

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