Pharmacokinetics of cefquinome in rainbow trout (Oncorhynchus mykiss) after intravascular, intraperitoneal, and oral administrations

Basit Öğe Kaydı
dc.authoridTerzi, Ertugrul/0000-0003-2811-6497
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.authoridBilen, Soner/0000-0001-9459-8178
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorCorum, Orhan
dc.contributor.authorTerzi, Ertugrul
dc.contributor.authorCoskun, Devran
dc.contributor.authorBilen, Soner
dc.contributor.authorCetin, Gul
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-12-24T19:29:35Z
dc.date.available2024-12-24T19:29:35Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study aimed to determine the pharmacokinetics and bioavailability of cefquinome in rainbow trout (Oncorhynchus mykiss) following intravascular (IV), intraperitoneal (IP), and oral (PO) administrations at 14 +/- 1 degrees C. In this study, three hundred and six clinically healthy rainbow trout (110-140 g) were used. The fish received single IV, IP, and PO injections of cefquinome at 10 mg/kg dose. The plasma concentrations of cefquinome were measured using HPLC-UV and were evaluated using non-compartmental analysis. Cefquinome was measured up to 96 h for PO route and 144 h for IV and IP routes in plasma. Following IV administration, t(1/2 lambda z), Cl-T, and V-dss were 18.85 h, 0.037 L/h/kg, and 0.84 L/kg, respectively. The C-max of IP and PO routes was 9.75 and 1.64 mu g/ml, respectively. The bioavailability following IP and PO administrations was 59.46% and 12.33%, respectively. Cefquinome at 10 mg/kg dose may maintain T > MIC above 40% at 72 and 96 h intervals, respectively, following the IP and IV routes for bacteria with MIC values of <= 2 mu g/ml and at 24 h intervals following the PO route for bacteria with MIC value of <= 0.75 mu g/ml. However, further studies are needed to determine in vitro and in vivo antibacterial efficacy and multiple dosage regimens of cefquinome against pathogens isolated from rainbow trout.
dc.identifier.doi10.1111/jvp.13091
dc.identifier.endpage583
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue6
dc.identifier.pmid36000461
dc.identifier.scopus2-s2.0-85136465530
dc.identifier.scopusqualityQ1
dc.identifier.startpage578
dc.identifier.urihttps://doi.org/10.1111/jvp.13091
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7150
dc.identifier.volume45
dc.identifier.wosWOS:000846697300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectbioavailability
dc.subjectcefquinome
dc.subjectpharmacokinetics
dc.subjectrainbow trout
dc.titlePharmacokinetics of cefquinome in rainbow trout (Oncorhynchus mykiss) after intravascular, intraperitoneal, and oral administrations
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu