Regulation of STAT3 and NF-κB signaling pathways by trans-Anethole in testicular ischemia-reperfusion injury and its gonadoprotective effect

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dc.contributor.authorSeker, Ugur
dc.contributor.authorGökçe, Yasin
dc.contributor.authorKati, Bulent
dc.contributor.authorYuksel, Meral
dc.contributor.authorGuzel, Baris Can
dc.contributor.authorShokoohi, Majid
dc.date.accessioned2024-12-24T19:09:48Z
dc.date.available2024-12-24T19:09:48Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractTesticular ischemia reperfusion (I/R) injury is a significant urological problem where clinical interventions may be inadequate, and the antioxidants might be potential co-treatment modalities. This study examined the gonadoprotective effect of trans-Anethole in testicular I/R injury. Twenty-eight male rats were divided into four groups. Rats in the I/R, I/R + t100, I/R + t200 groups underwent bilateral testicular I/R injury. The I/R + t100 and I/R + t200 groups received 100 or 200 mg/kg trans-Anethole at the 2nd hour of ischemia. Microscopic evaluations demonstrated that testicular I/R injury leads to severe testicular degeneration. Tissue oxidative stress, pro-apoptotic Bcl-2 associated X (Bax) and Caspase 3, pro-inflammatory Tumor necrosis factor-alpha (TNF-?), Interleukin-1 beta (IL-1?) and Interleukin 6 (IL-6) cytokines levels were significantly (p < 0.05) upregulated when compared to the Control group. Additionally, transcription factors Signal transducer and activator of transcription 3 (STAT3) and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) levels increased significantly (p < 0.05) compared to the Control group. Tissue disrupted parameters in the I/R + t200 group were significantly different (p < 0.05) from the I/R group, contrasting with the slight improvement in the I/R + t100 group. The STAT3 and NF-?B expression levels in the I/R + t200 group were significantly suppressed (p < 0.05) compared to the I/R group. In conclusion, our study indicates that trans-Anethole could enhance gonadoprotective activity in testicular I/R injury, potentially involving transcription factors STAT3 and NF-?B. However, before the consumption of trans-Anethole-containing natural or manufactured goods, the potential benefits and side effects should be carefully evaluated. © 2024 The Author(s).
dc.identifier.doi10.22514/j.androl.2024.015
dc.identifier.endpage67
dc.identifier.issn1698-031X
dc.identifier.issue3
dc.identifier.pmid39394750
dc.identifier.scopus2-s2.0-85206123282
dc.identifier.scopusqualityQ3
dc.identifier.startpage57
dc.identifier.urihttps://doi.org10.22514/j.androl.2024.015
dc.identifier.urihttps://hdl.handle.net/20.500.12604/3782
dc.identifier.volume22
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMRE Press
dc.relation.ispartofRevista Internacional de Andrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectApoptosis
dc.subjectInflammation
dc.subjectIschemia reperfusion injury
dc.subjectTestis
dc.subjecttrans-Anethole
dc.titleRegulation of STAT3 and NF-κB signaling pathways by trans-Anethole in testicular ischemia-reperfusion injury and its gonadoprotective effect
dc.title.alternativeRegulación de las vías de señalización de STAT3 y NF-?B por trans-Anetol en la lesión por isquemia-reperfusión testicular y su efecto gonadoprotector
dc.typeArticle

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