Antioxidant, antimicrobial, cytotoxic and protective effects of truffles

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dc.authoridali, muhammad muddassir/0000-0001-7930-7782
dc.contributor.authorFidan, Mehmet
dc.contributor.authorAli, Muhammad Muddassir
dc.contributor.authorErez, Mehmet Emre
dc.contributor.authorCigerci, Ibrahim Hakki
dc.contributor.authorOzdemir, Sadin
dc.contributor.authorSen, Fatih
dc.date.accessioned2024-12-24T19:25:08Z
dc.date.available2024-12-24T19:25:08Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractFungi can be used as a potent chemotherapeutic agent to treat various cancers. In current study acetone and methanol extracts of Terfezia claveryi, Terfezia boudieri, Terfezia olbiensis, Picoa lefebvrei, Picoa juniperi were used to assess total phenolic contents, antioxidant activity, ion-chelating impact, antimicrobial activity, the cytotoxic and protective effects. Both methanol and acetone extracts of T. boudieri had the highest FRAP and DPPH scavenging abilities. Dose-dependent increased ion-chelating impact of all tested truffles species was found. Extracts of T. boudieri, T. claveryi, and T. albiensis exhibited higher antimicrobial activities. T. claveryi and T. boudieri showed the highest protective effects against H2O2-induced genotoxicity (P < 0.05), in S. cerevisiae BY4741. The least protective effect was showed by the acetone extracts of T. olbiensis (144 +/- 8); methanol ex-tracts of P. lefebvrei (140 +/- 8) and P. juniperi (140 +/- 10). MCF 7 cells showed more sensitivity against to methanol extracts of T. boudieri at 10-100 mu g/mL concentrations. HepG2 cells showed more sensitivity against the methanolic extracts of T. boudieri at both doses. Overall, P. lefebvrei and P. juniperi extracts had the least cytotoxic effects. The species of Terfezia exhibit significant protective effects against DNA damage and also have the potential of cytotoxicity effects.
dc.identifier.doi10.1016/j.ab.2022.114566
dc.identifier.issn0003-2697
dc.identifier.issn1096-0309
dc.identifier.pmid35085547
dc.identifier.scopus2-s2.0-85123582170
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.ab.2022.114566
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6288
dc.identifier.volume641
dc.identifier.wosWOS:000793102100002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofAnalytical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectAnticancer
dc.subjectAntimicrobial
dc.subjectAntioxidant
dc.subjectDNA Cleavage activity
dc.subjectTruffles
dc.titleAntioxidant, antimicrobial, cytotoxic and protective effects of truffles
dc.typeArticle

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