Potential antioxidant, anticholinergic, antidiabetic and antiglaucoma activities and molecular docking of spiraeoside as a secondary metabolite of onion (Allium cepa)

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dc.authoridKARAGECILI, HASAN/0000-0001-6912-3998
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.contributor.authorDurmaz, Lokman
dc.contributor.authorKiziltas, Hatice
dc.contributor.authorKaragecili, Hasan
dc.contributor.authorAlwasel, Saleh
dc.contributor.authorGulcin, Lhami
dc.date.accessioned2024-12-24T19:27:28Z
dc.date.available2024-12-24T19:27:28Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractOnion contains many dietary and bioactive components including phenolics and flavonoids. Spiraeoside (quercetin-4-O-b-D-glucoside) is one of the most putative flavonoids in onion. Several antioxidant techniques were used in this investigation to assess the antioxidant capabilities of spiraeoside, including 1,1diphenyl-2-picrylhydrazyl radical (DPPHGreek ano teleia) scavenging, N,N-dimethyl-p-phenylenediamine radical (DMPD'') scavenging, 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulphonate) radical (ABTS'') scavenging activities, cupric ions (Cu2') reducing and potassium ferric cyanide reduction abilities. In contrast, the water-soluble a-tocopherol analogue trolox and the conventional antioxidants butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and a-tocopherol were utilized as the standards for evaluation. Spiraeoside scavenged the DPPH radicals an IC50 of 28.51 mu g/mL (r2: 0.9705) meanwhile BHA, BHT, trolox, and a-tocopherol displayed IC50 of 10.10 mu g/mL (r2: 0.9015), 25.95 mu g/mL (r2: 0.9221), 7.059 mu g/mL (r2: 0.9614) and 11.31 mu g/mL (r2: 0.9642), accordingly. The results exhibited that spiraeoside had effects similar to BHT, but less potent than a-tocopherol, trolox and BHA. Also, inhibitory effects of spiraeoside were evaluated toward some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase II (CA II) and a-glycosidase, which are related to a number of illnesses, such as Alzheimer's disease (AD), diabetes mellitus and glaucoma disorder. Spiraeoside exhibited IC50 values of 4.44 nM (r2: 0.9610), 7.88 nM (r2: 0.9784), 19.42 nM (r2: 0.9673) and 29.17 mM (r2: 0.9209), respectively against these enzymes. Enzyme inhibition abilities were compared to clinical used inhibitors including acetazolamide (for CA II), tacrine (for AChE and BChE) and acarbose (for a-glycosidase). Spiraeoside demonstrated effective antioxidant, anticholinergic, antidiabetic and antiglaucoma activities. With these properties, it has shown that Spiraeoside has the potential to be a medicine for some metabolic diseases. (c) 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.description.sponsorshipTUBA; King Saud University [RSP-2023/59]
dc.description.sponsorshipIlhami Gulcin is an affiliate of the Turkish Academy of Sciences (TUBA) . He really wants to express his heartfelt gratitude to the TUBA for their financial assistance. Saleh Alwasel would like to express his profound thanks to the King Saud University, Researchers Supporting Projects (RSP-2023/59) .
dc.identifier.doi10.1016/j.jsps.2023.101760
dc.identifier.issn1319-0164
dc.identifier.issn2213-7475
dc.identifier.issue10
dc.identifier.pmid37693735
dc.identifier.scopus2-s2.0-85169818991
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jsps.2023.101760
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6642
dc.identifier.volume31
dc.identifier.wosWOS:001078411700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofSaudi Pharmaceutical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectSpiraeoside
dc.subjecta-glycosidase
dc.subjectEnzyme inhibition
dc.subjectCarbonic anhydrase
dc.subjectAntioxidant activity
dc.subjectAcetylcholinesterase
dc.titlePotential antioxidant, anticholinergic, antidiabetic and antiglaucoma activities and molecular docking of spiraeoside as a secondary metabolite of onion (Allium cepa)
dc.typeArticle

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