Alternations in nuclear factor kappa beta activity (NF-kB) in the rat brain due to long-term use of atomoxetine for treating ADHD: In vivo and in silico studies

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dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.authoridGUR, Fatma/0000-0001-5983-1472
dc.contributor.authorGur, Fatma
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorGur, Bahri
dc.date.accessioned2024-12-24T19:25:21Z
dc.date.available2024-12-24T19:25:21Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractAttention Deficit Hyperactivity Disorder (ADHD) is the most common psychiatric disorder reported particularly in children. Long-term use of antipsychotic drugs used in the treatment of ADHD has been shown to exert toxic effects on the brain. However, not enough research has been carried out on the neurotoxic effects of these drugs on the brain tissue. Atomoxetine (ATX) is the most widely used antipsychotic drug that has gained approval for ADHD treatment. The present study aims to determine the damage induced by long-term use of three different doses of ATX in the brain tissue of experimental rats. 24 rats were divided into Control group (0.5 mL saline), Group 2 (0.5 mg/mL ATX), Group 3 (1.0 mg/mL ATX), and Group 4 (2.0 mg/mL ATX), each group having 6 members. Their brain tissues were taken for stereological, histological, and nuclear factor kappa-B (NF-kB) protein expression analysis. ATX was determined to have caused a few alterations in the brain tissue, such as disruption in the endothelial epithelium of capillaries, a couple of large astrocyte nuclei, and mitotic astrocytes. Moreover, a significant difference was observed in Group 4 compared to Control Group in terms of astrocyte counts in the brain sections. As for Groups 3 and 4, there were differences in terms of oligodendrocyte counts in the incisions cultivated from the brain tissues of the animals. On the other hand, NF-kB positive astrocytes of Groups 3 and 4 differed significantly from those of Control and Group 2. The results of molecular dockings of the present study are in line with the in-vivo results. Therefore, it was concluded that the higher the dose of ATX was, the more damage the brain tissue sustained. (c) 2020 Elsevier Inc. All rights reserved.
dc.description.sponsorshipScientific Research Fund of Ataturk University Project Council [2009/102]; Ataturk University
dc.description.sponsorshipThe financial support by Scientific Research Fund of Ataturk University Project Council (Project No. 2009/102) is gratefully acknowledged. The authors thank Ataturk University for its generous support.
dc.identifier.doi10.1016/j.bbrc.2020.10.072
dc.identifier.endpage932
dc.identifier.issn0006-291X
dc.identifier.issn1090-2104
dc.identifier.pmid33143874
dc.identifier.scopus2-s2.0-85094899729
dc.identifier.scopusqualityQ2
dc.identifier.startpage927
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2020.10.072
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6375
dc.identifier.volume534
dc.identifier.wosWOS:000614555200009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectADHD
dc.subjectAtomoxetine
dc.subjectNuclear kappa-B
dc.subjectStereological analyses
dc.subjectMolecular docking
dc.titleAlternations in nuclear factor kappa beta activity (NF-kB) in the rat brain due to long-term use of atomoxetine for treating ADHD: In vivo and in silico studies
dc.typeArticle

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