Investigation into the protective effects of Hypericum Triquetrifolium Turra seed against cyclophosphamide-induced testicular injury in Sprague Dawley rats

Basit Öğe Kaydı
dc.authoridCETIK YILDIZ, Songul/0000-0002-7855-5343
dc.authoridKeskin, Cumali/0000-0003-3758-0654
dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.contributor.authorCan, Senanur
dc.contributor.authorYildiz, Songul Cetik
dc.contributor.authorKeskin, Cumali
dc.contributor.authorSahinturk, Varol
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorBaskoy, Sila Appak
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:28:03Z
dc.date.available2024-12-24T19:28:03Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractFor centuries, Turkey has been a significant location here around 80 species of Hypericum with differing names widely occur, which is also known as Turkish folk medicine in treating some bacterial diseases as well as stomach and intestine inflammation. Recent studies have reported this herb family to contain numbers of bioactive compound contents. The study aims to investigate the protective effects of Hypericum triquetrifolium Turra (HT) upon oxidative stress and apoptosis in a rat model in which testes injury was induced by CP. The testicular injury was caused using CP (150mg/kg). The rats were treated with a single dose (100mg/kg) of methanol extract of HT to investigate various biochemical markers in the serum and plasma of blood samples apart from assessing the prognosis of CP-induced testicular damage. Added to that, histological analyses were performed to identify possible structural changes and apoptotic indicators, like Bax, Caspase-3, and Bcl-2. In CP Group, there was a rise in the levels of total oxidant status (TOS), malondialdehyde (MDA), oxidative stress index (OSI), Caspase-3, and Bax while superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), Bcl-2, and total antioxidant capacity (TAC) all decreased. Also, our histological analysis showed damaged testes. On the other hand, neither biochemical nor histological analysis showed testicular damage in HT Alone Group. In CP+HT Group, a significant number of the negatives changes due to CP were observed to have improved remarkably following an HT treatment. This study results suggest that HT could help improve CP-induced testicular injury thanks to its anti-oxidative and anti-apoptotic properties. [GRAPHICS] . HIGHLIGHTS The present study is the first of its kind in the sense that it investigated the effects of Hypericum triquetrifolium Turra (HT) on the testicular injury that is attributable to cyclophosphamide (CP), which is a drug used for chemotherapy. Confocal and light microscopic analyses revealed that HT reduced CP-related oxidative stress, apoptosis, and tissue damage in statistically significant amounts. The antioxidant properties of HT appear to account for the protective effects of HT upon experimentally induced tissue damage.
dc.description.sponsorshipScientific Research Projects Coordination Department at Mardin Artuklu University [MAU-BAP-15-SHMYO-23]
dc.description.sponsorshipThe present study gained approval from Local Animal Experiment Ethics Committee at Eskisehir Osmangazi University [numbered 444-1/2015] and was supported by Scientific Research Projects Coordination Department at Mardin Artuklu University [MAU-BAP-15-SHMYO-23].
dc.identifier.doi10.1080/01480545.2020.1856130
dc.identifier.endpage1686
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue4
dc.identifier.pmid33280440
dc.identifier.scopus2-s2.0-85097139015
dc.identifier.scopusqualityQ1
dc.identifier.startpage1679
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1856130
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6905
dc.identifier.volume45
dc.identifier.wosWOS:000596284100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectCyclophosphamide
dc.subjecttesticular toxicity
dc.subjectHypericum triquetrifolium
dc.subjectTurra
dc.subjectanti-oxidant
dc.subjectanti-apoptotic
dc.titleInvestigation into the protective effects of Hypericum Triquetrifolium Turra seed against cyclophosphamide-induced testicular injury in Sprague Dawley rats
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu