Effect of Age on the Pharmacokinetics of Marbofloxacin Following Intravenous Administration in Calves

Basit Öğe Kaydı
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.contributor.authorCorum, Orhan
dc.contributor.authorYuksel, Murat
dc.contributor.authorCoskun, Devran
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorKartal, Serafettin
dc.contributor.authorCellat, Mustafa
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-12-24T19:29:35Z
dc.date.available2024-12-24T19:29:35Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractThe aim of this study was to compare the pharmacokinetics of marbofloxacin after intravenous (IV) administration of a single dose of 10 mg/kg to calves of different ages. The study was carried on 1- (n = 6), 2- (n = 6), and 4-month-old (n = 6) Montofon calves. Plasma concentrations of marbofloxacin were measured using HPLC, and pharmacokinetic data were calculated by non-compartmental analysis. The elimination half-life (t(1/2 lambda z)), volume of distribution at steady state (V-dss), total clearance (Cl-T), and area under the concentration-versus time curve (AUC(0-infinity)) values of marbofloxacin in 1-month-old calves were 10.62 h, 1.03 L/kg, 0.08 L/h/kg, and 127.90 h*mu g/mL, respectively. While the t(1/2 lambda z) (from 10.62 to 3.36 h) and AUC(0-infinity) (from 127.90 to 47.35 h*mu g/mL) decreased in parallel with the age of the calves, Cl-T (from 0.08 to 0.21 L/h/kg) increased. The V-dss of marbofloxacin was higher in 1- and 2-month-old calves compared to 4-month-old calves. After IV administration of marbofloxacin at a dose of 10 mg/kg, an fAUC(0-24)/MIC90 ratio of >= 125 was obtained for bacteria with MIC90 values of <= 0.60, <= 0.39 and <= 0.27 mu g/mL in 1-, 2-, and 4-month-old calves, respectively. These results show that the antibacterial effect of marbofloxacin, which has concentration-dependent activity, decreases due to age-related pharmacokinetic changes and that the 10 mg/kg dose should be reviewed according to the MIC90 value of the bacteria.
dc.identifier.doi10.1111/jvp.13483
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.pmid39285847
dc.identifier.scopus2-s2.0-85204237804
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/jvp.13483
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7154
dc.identifier.wosWOS:001314208300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectage
dc.subjectcalves
dc.subjectmarbofloxacin
dc.subjectpharmacodynamics
dc.subjectpharmacokinetics
dc.titleEffect of Age on the Pharmacokinetics of Marbofloxacin Following Intravenous Administration in Calves
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu