Antioxidant properties of Rosa pisiformis and its protective effect against isoproterenol-induced oxidative stress in rats

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dc.authoridEkin, Suat/0000-0002-6502-5028
dc.authoridBayramoglu AKKOYUN, Mahire/0000-0001-5150-5402
dc.authoridOZGOKCE, FEVZI/0000-0002-3119-8561
dc.contributor.authorBayramoglu, Mahire
dc.contributor.authorEkin, Suat
dc.contributor.authorKiziltas, Hatice
dc.contributor.authorOto, Gokhan
dc.contributor.authorSusen, Ebru Altindal
dc.contributor.authorOzgokce, Fevzi
dc.date.accessioned2024-12-24T19:30:08Z
dc.date.available2024-12-24T19:30:08Z
dc.date.issued2016
dc.departmentSiirt Üniversitesi
dc.description.abstractObjective: In this study, Rosa pisiformis was evaluated for its antioxidant activity, vitamin (A, E, C), trace element (Fe, Cu, Zn, Mn, Cr, Se) and mineral (Ca, K, Mg, Na) levels, in addition to its cardioprotective effects on cardiac tissue antioxidant enzymes (GSH-Px, SOD, CAT) during isoproterenol (ISO)-induced oxidative stress. Methods: In the study, vitamin and mineral analysis was carried out using HPLC and ICP-MS method, R. P. antioxidant and antiradical properties were determined using spectrophotometer. Forty wistar albino rats were divided into four groups: control (0.9% NaCl), ISO (100 mg/kg), ISO (100 mg/kg) + R. P. (300 mg/kg) and R. P. (300 mg/kg). ISO was injected subcutaneously into rats twice at an interval of 24 h for two consecutive days (on 28(th) and 29(th) day). R. P. fruit administered daily. The experimental period was continued for 30 days. Results: The results of the study indicated that R. P. fruit and leaves contain high levels of minerals and vitamins and possess antioxidant and antiradical activity and its fruits have positive effects on cardiac tissues. The results are supported with significant changes in antioxidant enzyme levels and histopathological examination. Conclusion: This study demonstrates that R. P. fruits in particular can be used to treat and prevent cardiac diseases.
dc.description.sponsorshipScientific Research Projects Presidency of Yuzuncu Yil University [2012-FBE-D015]
dc.description.sponsorshipThe study was supported by a grant from the Scientific Research Projects Presidency of Yuzuncu Yil University (2012-FBE-D015).
dc.identifier.doi10.1515/tjb-2016-0034
dc.identifier.endpage242
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84982812976
dc.identifier.scopusqualityQ3
dc.identifier.startpage232
dc.identifier.trdizinid224905
dc.identifier.urihttps://doi.org/10.1515/tjb-2016-0034
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/224905
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7408
dc.identifier.volume41
dc.identifier.wosWOS:000387205500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectRosa pisiformis
dc.subjectIsoproterenol
dc.subjectTrace element
dc.subjectVitamin
dc.subjectAntioxidant enzymes
dc.titleAntioxidant properties of Rosa pisiformis and its protective effect against isoproterenol-induced oxidative stress in rats
dc.title.alternativeRosa pisiformis’in antioksidant özellikleri ve izoproterenol ile ratlarda oluşturulan okdidatif strese karşı koruyucu etkisi
dc.typeArticle

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